The dopamine D1 and D2 receptors are major receptors in the regulation of striatal function
and striatal adenosine A1 and A2A receptors are major modulators of their signaling. The …

The existence of A 2A-D 2 heteromeric complexes is based on coimmunoprecipitation
studies and on fluorescence resonance energy transfer and bioluminescence resonance …

Caffeine produces mild psychostimulant and sometimes anxiogenic effects by antagonizing
adenosine at A 1 and A 2A receptors, and perhaps through interactions with other …

Adenosine is a naturally occurring nucleoside that is distributed ubiquitously throughout the
body as a metabolic intermediary. In the brain, adenosine functions as an important …

Adenosine–dopamine interactions in the central nervous system (CNS) have been studied
for many years in view of their relevance for disorders of the CNS and their treatments. The …

Future therapies in Parkinson's disease may substantially build on the existence of intra‐
membrane receptor–receptor interactions in DA receptor containing heteromeric receptor …

Adenosine A2A and dopamine D2 receptors have been shown previously to form
heteromeric complexes and interact at the level of agonist binding, G protein coupling, and …

Abstract Dopamine D2 L R-serotonin 5-HT2AR heteromers were demonstrated in HEK293
cells after cotransfection of the two receptors and shown to have bidirectional receptor …

In 1980/81 Agnati and Fuxe introduced the concept of intramembrane receptor–receptor
interactions and presented the first experimental observations for their existence in crude …

G protein‐coupled receptors are one of the most actively studied families of proteins.
However, despite the ubiquity of protein dimerization and oligomerization as a structural and …