Genomes assembled de novo from short reads are highly fragmented relative to the finished
chromosomes of Homo sapiens and key model organisms generated by the Human …

In biology as in real estate, location is a cardinal organizational principle that dictates the
accessibility and flow of informational traffic. An essential question in nuclear organization is …

INTRODUCTION The rhesus macaque (Macaca mulatta) is one of the most widely used
nonhuman primate (NHP) models for studying human biology and disease. As a …

Open questions: How many genes do we have? | BMC Biology Skip to main content
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Motivation: For most research approaches, genome analyses are dependent on the
existence of a high quality genome reference assembly. However, the local accuracy of an …

The GENCODE Consortium aims to identify all gene features in the human genome using a
combination of computational analysis, manual annotation, and experimental validation …

The use of CRISPR/Cas9 as a genome-editing tool in various model organisms has
radically changed targeted mutagenesis. Here, we present a high-throughput targeted …

Systematic studies of the cancer genome have exploded in recent years. These studies
have revealed scores of new cancer genes, including many in processes not previously …

Shedding of microbial extracellular vesicles constitutes a universal mechanism for inter-
kingdom and intra-kingdom communication that is conserved among prokaryotic and …

Determining the full complement of protein-coding genes is a key goal of genome
annotation. The most powerful approach for confirming protein-coding potential is the …