Oxidative stress in the pathophysiology of type 2 diabetes and related complications: Current therapeutics strategies and future perspectives
JS Bhatti, A Sehrawat, J Mishra, IS Sidhu… - Free Radical Biology …, 2022 - Elsevier
Abstract Type 2 diabetes (T2DM) is a persistent metabolic disorder rising rapidly worldwide.
It is characterized by pancreatic insulin resistance and β-cell dysfunction. Hyperglycemia …
It is characterized by pancreatic insulin resistance and β-cell dysfunction. Hyperglycemia …
A brief review of phenolic compounds identified from plants: Their extraction, analysis, and biological activity
Y Zhang, P Cai, G Cheng… - Natural product …, 2022 - journals.sagepub.com
Phenolic compounds are the most abundant secondary metabolites in plants, showing a
wide range of distinct biological activities, have received more and more attention in recent …
wide range of distinct biological activities, have received more and more attention in recent …
[HTML][HTML] RONS and oxidative stress: An overview of basic concepts
AK Aranda-Rivera, A Cruz-Gregorio… - Oxygen, 2022 - mdpi.com
Oxidative stress (OS) has greatly interested the research community in understanding
damaging processes occurring in cells. OS is triggered by an imbalance between reactive …
damaging processes occurring in cells. OS is triggered by an imbalance between reactive …
[HTML][HTML] Reactive oxygen species-based nanomaterials for the treatment of myocardial ischemia reperfusion injuries
Interventional coronary reperfusion strategies are widely adopted to treat acute myocardial
infarction, but morbidity and mortality of acute myocardial infarction are still high …
infarction, but morbidity and mortality of acute myocardial infarction are still high …
[HTML][HTML] Plant-derived anticancer compounds as new perspectives in drug discovery and alternative therapy
CA Dehelean, I Marcovici, C Soica, M Mioc… - Molecules, 2021 - mdpi.com
Despite the recent advances in the field of chemically synthetized pharmaceutical agents,
nature remains the main supplier of bioactive molecules. The research of natural products is …
nature remains the main supplier of bioactive molecules. The research of natural products is …
[HTML][HTML] Glutathione system enhancement for cardiac protection: pharmacological options against oxidative stress and ferroptosis
M Tan, Y Yin, X Ma, J Zhang, W Pan, M Tan… - Cell Death & …, 2023 - nature.com
The glutathione (GSH) system is considered to be one of the most powerful endogenous
antioxidant systems in the cardiovascular system due to its key contribution to detoxifying …
antioxidant systems in the cardiovascular system due to its key contribution to detoxifying …
Transcription factor NRF2 as a therapeutic target for chronic diseases: a systems medicine approach
Systems medicine has a mechanism-based rather than a symptom-or organ-based
approach to disease and identifies therapeutic targets in a nonhypothesis-driven manner. In …
approach to disease and identifies therapeutic targets in a nonhypothesis-driven manner. In …
[HTML][HTML] Anti-obesity effects of polyphenol intake: Current status and future possibilities
M Boccellino, S D'Angelo - International journal of molecular sciences, 2020 - mdpi.com
The prevalence of obesity has steadily increased worldwide over the past three decades.
The conventional approaches to prevent or treat this syndrome and its associated …
The conventional approaches to prevent or treat this syndrome and its associated …
[HTML][HTML] Chronic stress and oxidative stress as common factors of the pathogenesis of depression and Alzheimer's disease: The role of antioxidants in prevention and …
G Juszczyk, J Mikulska, K Kasperek, D Pietrzak… - Antioxidants, 2021 - mdpi.com
There is a growing body of scientific research showing the link between depression and
dementia in Alzheimer's disease (AD). The chronic stress contributes to the formation of …
dementia in Alzheimer's disease (AD). The chronic stress contributes to the formation of …
Shell-sheddable polymeric micelles alleviate oxidative stress and inflammation for enhanced ischemic stroke therapy
Z Wang, J Pan, R Yuan, M Chen, X Guo, S Zhou - Nano Letters, 2023 - ACS Publications
As a ROS scavenger, resveratrol exerts a neuroprotective effect by polarizing the M1
microglia to the anti-inflammatory M2 phenotype for ischemic stroke treatment. However, the …
microglia to the anti-inflammatory M2 phenotype for ischemic stroke treatment. However, the …