Detection, structure and function of modified DNA bases
While some DNA base modifications such as 5-methylcytosine have been known and
studied for decades, recent discoveries of a number of other modified bases have stimulated …
studied for decades, recent discoveries of a number of other modified bases have stimulated …
[HTML][HTML] Chemical methods for decoding cytosine modifications in DNA
MJ Booth, EA Raiber, S Balasubramanian - Chemical reviews, 2015 - ACS Publications
Genetic information is encoded by the four bases adenine (A), guanine (G), cytosine (C),
and thymine (T). Base pairing through hydrogen bonding between the cognate pairs AT and …
and thymine (T). Base pairing through hydrogen bonding between the cognate pairs AT and …
5-hydroxymethylcytosine in cancer: significance in diagnosis and therapy
A Vasanthakumar, LA Godley - Cancer genetics, 2015 - Elsevier
Emerging data have demonstrated that 5-methylcytosine (5-mC) and its oxidized products 5-
hydroxymethylcytosine (5-hmC), 5-formylcytosine (5-fC), and 5-carboxylcytosine (5-CaC) …
hydroxymethylcytosine (5-hmC), 5-formylcytosine (5-fC), and 5-carboxylcytosine (5-CaC) …
Reversible DNA–Protein Cross‐Linking at Epigenetic DNA Marks
Formylcytosine (5fC) is an endogenous DNA modification frequently found within regulatory
elements of mammalian genes. Although 5fC is an oxidation product of 5‐methylcytosine …
elements of mammalian genes. Although 5fC is an oxidation product of 5‐methylcytosine …
[HTML][HTML] DNAmod: the DNA modification database
AJ Sood, C Viner, MM Hoffman - Journal of cheminformatics, 2019 - Springer
Covalent DNA modifications, such as 5-methylcytosine (5mC), are increasingly the focus of
numerous research programs. In eukaryotes, both 5mC and 5-hydroxymethylcytosine …
numerous research programs. In eukaryotes, both 5mC and 5-hydroxymethylcytosine …
Epigenomics in marine fishes
DCH Metzger, PM Schulte - Marine Genomics, 2016 - Elsevier
Epigenetic mechanisms are an underappreciated and often ignored component of an
organism's response to environmental change and may underlie many types of phenotypic …
organism's response to environmental change and may underlie many types of phenotypic …
Whole-genome mapping of epigenetic modification of 5-formylcytosine at single-base resolution by chemical labeling enrichment and deamination sequencing
JH Ding, G Li, J Xiong, FL Liu, NB Xie, TT Ji… - Analytical …, 2024 - ACS Publications
DNA cytosine methylation (5-methylcytosine, 5mC) is a predominant epigenetic modification
that plays a critical role in a variety of biological and pathological processes in mammals. In …
that plays a critical role in a variety of biological and pathological processes in mammals. In …
The impact of DNA methylation in hematopoietic malignancies
Aberrant DNA methylation is a characteristic feature of cancers including blood
malignancies. Mutations in the DNA methylation regulators DNMT3A, TET1/2, and IDH1/2 …
malignancies. Mutations in the DNA methylation regulators DNMT3A, TET1/2, and IDH1/2 …
[HTML][HTML] A sensitive approach to map genome-wide 5-hydroxymethylcytosine and 5-formylcytosine at single-base resolution
Summary Mapping genome-wide 5-hydroxymethylcytosine (5hmC) and 5-formylcytosine
(5fC) at single-base resolution is important to understand their biological functions. We …
(5fC) at single-base resolution is important to understand their biological functions. We …
[HTML][HTML] Base-resolution maps of 5-formylcytosine and 5-carboxylcytosine reveal genome-wide DNA demethylation dynamics
The TET family of dioxygenases can oxidize 5-methylcytosine (5mC) to 5-
hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC) in …
hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC) in …