Applications of multi‐omics analysis in human diseases

C Chen, J Wang, D Pan, X Wang, Y Xu, J Yan… - MedComm, 2023 - Wiley Online Library
Multi‐omics usually refers to the crossover application of multiple high‐throughput screening
technologies represented by genomics, transcriptomics, single‐cell transcriptomics …

Cellular senescence of renal tubular epithelial cells in acute kidney injury

J Chen, H Zhang, X Yi, Q Dou, X Yang, Y He… - Cell Death …, 2024 - nature.com
Cellular senescence represents an irreversible state of cell-cycle arrest during which cells
secrete senescence-associated secretory phenotypes, including inflammatory factors and …

The key cellular senescence related molecule RRM2 regulates prostate cancer progression and resistance to docetaxel treatment

B Cheng, L Li, Y Wu, T Luo, C Tang, Q Wang, Q Zhou… - Cell & Bioscience, 2023 - Springer
Background Prostate cancer is a leading cause of cancer-related deaths among men
worldwide. Docetaxel chemotherapy has proven effective in improving overall survival in …

Integrated Stress Response (ISR) Pathway: Unraveling Its Role in Cellular Senescence

A Kalinin, E Zubkova, M Menshikov - International Journal of Molecular …, 2023 - mdpi.com
Cellular senescence is a complex process characterized by irreversible cell cycle arrest.
Senescent cells accumulate with age, promoting disease development, yet the absence of …

Bioinformatics for wet-lab scientists: practical application in sequencing analysis

V Laub, K Devraj, L Elias, D Schulte - BMC genomics, 2023 - Springer
Background Genomics data is available to the scientific community after publication of
research projects and can be investigated for a multitude of research questions. However, in …

HDAC4 influences the DNA damage response and counteracts senescence by assembling with HDAC1/HDAC2 to control H2BK120 acetylation and homology …

E Di Giorgio, E Dalla, V Tolotto, F D'Este… - Nucleic Acids …, 2024 - academic.oup.com
Access to DNA is the first level of control in regulating gene transcription, a control that is
also critical for maintaining DNA integrity. Cellular senescence is characterized by profound …

Downregulation of Krüppel‐like factor 14 accelerated cellular senescence and aging

Y Hou, Q Song, Y Wang, J Liu, Y Cui, X Zhang… - Aging …, 2023 - Wiley Online Library
Aging has been considered as a risk factor in many diseases, thus, comprehensively
understanding the cellular and molecular mechanisms of delayed aging is important. Here …

A strategy for the treatment of gastrointestinal cancer: Targeting tumor senescent cells

Y Liu, Q Zhang, W Ni, G Ji, H Xu - Frontiers in Molecular Biosciences, 2023 - frontiersin.org
Gastrointestinal (GI) cancer includes a variety of cancers with high incidence that seriously
threaten the lives of people worldwide. Although treatment strategies continue to improve …

Integrated ATAC-seq and RNA-seq Analysis of In Vitro Cultured Skeletal Muscle Satellite Cells to Understand Changes in Cell Proliferation

Z Ren, S Zhang, L Shi, A Zhou, X Lin, J Zhang, X Zhu… - Cells, 2024 - mdpi.com
Skeletal muscle satellite cells, the resident stem cells in pig skeletal muscle, undergo
proliferation and differentiation to enable muscle tissue repair. The proliferative and …

Extracellular vesicle-derived TP53BP1, CD34, and PBX1 from human peripheral blood serve as potential biomarkers for the assessment and prediction of vascular …

Y Wen, H Chen, Y Wang, Y Sun, F Dou, X Du, T Liu… - Hereditas, 2024 - Springer
Background Vascular aging is an important pathophysiological basis for the senescence of
various organs and systems in the human body, and it is a common pathogenetic trigger for …