Voriconazole is a potent triazole with broad-spectrum antifungal activity against clinically
significant and emerging pathogens. The present population pharmacokinetic analysis …

A series of substituted piperazine derivatives have been synthesized and tested for
antimicrobial activity. The antibacterial activity was tested against Staphylococcus aureus …

BACKGROUND Caspofungin (CAS) as salvage therapy for refractory invasive aspergillosis
(IA) had a response rate of 45% among a heterogeneous group of patients. The use of CAS …

ABSTRACT Mycograb (Neu Tec Pharma plc) is a human genetically recombinant antibody
against fungal heat shock protein 90 (HSP90). Antibody to HSP90 is closely associated with …

The incidence of invasive fungal infections (IFIs) has increased over the past two decades,
as the populations of patients at risk have continued to rise. Early and accurate diagnosis …

Invasive Candida infections are important causes of morbidity and mortality in
immunocompromised and hospitalised patients. This article provides the joint …

Background. Although rotaviruses (RVs) are the most common cause of severe
gastroenteritis in children, there is a lack of information detailing the spectrum of clinical …

The hydroxypyridone ciclopirox olamine belongs to the antimycotic drugs used for the
treatment of superficial mycoses. In contrast to the azoles and other antimycotic drugs, its …

In vivo pharmacodynamic parameters have been described for a variety of antibacterials.
These parameters have been studied in correlation with in vivo outcomes in order to …

Antifungal compounds exert their activity through a variety of mechanisms, some of which
are poorly understood. Novel approaches to characterize the mechanism of action of …