Abstract Introduction The protein Klotho (KL) was first discovered in KL-deficient mice, which
developed a syndrome similar to premature aging in humans. Since then, KL has been …

The discovery of the Klotho (KL) gene, which was originally identified as a putative aging-
suppressor gene, has generated tremendous interest and has advanced understanding of …

Rationale: Cardiac aging is an important contributing factor for heart failure, which affects a
large population but remains poorly understood. Objective: The purpose of this study is to …

A wealth of observational studies show that low testosterone is associated with insulin
resistance and with an increased risk of diabetes and the metabolic syndrome. Experimental …

The human microbiome contains a vast array of microbes and genes that show greater
complexity than the host's own karyome; the functions of many of these microbes are …

Abstract αKlotho (called Klotho here) is a membrane protein that serves as the coreceptor for
the circulating hormone fibroblast growth factor 23 (FGF23). Klotho is also cleaved and …

Background αKlotho is the prototypic member of the Klotho family and is most highly
expressed in the kidney. αKlotho has pleiotropic biologic effects, and in the kidney, its …

Aging is an inevitable and progressive biological process involving dysfunction and
eventually destruction of every tissue and organ. This process is driven by a tightly regulated …

CKD appears to be a condition of soluble klotho deficiency. Despite known associations
between low soluble klotho levels and conditions that promote kidney damage, such as …

Klotho is a membrane-bound protein predominantly expressed in the kidney, where it acts
as a permissive co-receptor for Fibroblast Growth Factor 23. In its shed form, Klotho exerts …