[HTML][HTML] Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR inhibitors: rationale and importance to inhibiting these pathways in human health
WH Chappell, LS Steelman, JM Long, RC Kempf… - Oncotarget, 2011 - ncbi.nlm.nih.gov
Abstract The Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades are often activated by
genetic alterations in upstream signaling molecules such as receptor tyrosine kinases …
genetic alterations in upstream signaling molecules such as receptor tyrosine kinases …
[HTML][HTML] Role of the PI3K/AKT and mTOR signaling pathways in acute myeloid leukemia
S Park, N Chapuis, J Tamburini, V Bardet… - …, 2010 - ncbi.nlm.nih.gov
Abstract The PI3K/AKT and mTOR signaling pathways are activated in acute myeloid
leukemia, including in the more immature leukemic populations. Constitutive PI3K activation …
leukemia, including in the more immature leukemic populations. Constitutive PI3K activation …
PVP-coated silver nanoparticles and silver ions induce reactive oxygen species, apoptosis and necrosis in THP-1 monocytes
R Foldbjerg, P Olesen, M Hougaard, DA Dang… - Toxicology letters, 2009 - Elsevier
The objective of the present study was to investigate the toxicity of silver nanoparticles (Ag
NPs) in vitro. Silver ions (Ag+) have been used in medical treatments for decades whereas …
NPs) in vitro. Silver ions (Ag+) have been used in medical treatments for decades whereas …
[HTML][HTML] The phosphatidylinositol 3-kinase/Akt/mTOR signaling network as a therapeutic target in acute myelogenous leukemia patients
AM Martelli, C Evangelisti, F Chiarini, JA McCubrey - Oncotarget, 2010 - ncbi.nlm.nih.gov
Abstract The phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin
(mTOR) signaling axis plays a central role in cell proliferation, growth, and survival under …
(mTOR) signaling axis plays a central role in cell proliferation, growth, and survival under …
Contribution of bone microenvironment to leukemogenesis and leukemia progression
F Ayala, R Dewar, M Kieran, R Kalluri - Leukemia, 2009 - nature.com
Tumor microenvironment has a major role in cancer progression and resistance to
treatment. The bone marrow (BM) is a dynamic network of growth factors, cytokines and …
treatment. The bone marrow (BM) is a dynamic network of growth factors, cytokines and …
Perifosine: update on a novel Akt inhibitor
JJ Gills, PA Dennis - Current oncology reports, 2009 - Springer
Abstract The PI3K/Akt/mTOR pathway is aberrantly active in most human cancers and
contributes to cell growth, proliferation, and survival. Akt is a nodal regulator of cellular …
contributes to cell growth, proliferation, and survival. Akt is a nodal regulator of cellular …
Leukemic stem cells: identification and clinical application
D Hanekamp, J Cloos, GJ Schuurhuis - International journal of hematology, 2017 - Springer
Leukemic stem cells (LSCs) in acute myeloid leukemia (AML) represent a low-frequency
subpopulation of leukemia cells that possess stem cell properties distinct from the bulk …
subpopulation of leukemia cells that possess stem cell properties distinct from the bulk …
Targeting survival cascades induced by activation of Ras/Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways for effective leukemia therapy
JA McCubrey, LS Steelman, SL Abrams, FE Bertrand… - Leukemia, 2008 - nature.com
Abstract The Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways are frequently
activated in leukemia and other hematopoietic disorders by upstream mutations in cytokine …
activated in leukemia and other hematopoietic disorders by upstream mutations in cytokine …
PI-103, a dual inhibitor of Class IA phosphatidylinositide 3-kinase and mTOR, has antileukemic activity in AML
Abstract The phosphatidylinositol 3-kinase (PI3K)/Akt and mammalian target of rapamycin
complex 1 (mTORC1) signaling pathways are frequently activated in acute myelogenous …
complex 1 (mTORC1) signaling pathways are frequently activated in acute myelogenous …
The PI3K/PKB signaling module as key regulator of hematopoiesis: implications for therapeutic strategies in leukemia
R Polak, M Buitenhuis - Blood, The Journal of the American …, 2012 - ashpublications.org
An important mediator of cytokine signaling implicated in regulation of hematopoiesis is the
PI3K/protein kinase B (PKB/c-Akt) signaling module. Constitutive activation of this signaling …
PI3K/protein kinase B (PKB/c-Akt) signaling module. Constitutive activation of this signaling …