Background Acute myeloid leukemia (AML) is a heterogeneous disorder with aberrant
regulation of a variety of signal pathways. Therefore, simultaneous targeting of two or even …

For the last twenty years, significant progress in Molecular and Cellular Biology has resulted
in a better characterization and understanding of the biology and prognosis of acute myeloid …

Alkylphospholipids and alkylphosphocholines (APCs) are promising antitumor agents,
which target the plasma membrane and affect multiple signal transduction networks. We …

Background Perifosine, an alkylphospholipid, is an Akt inhibitor which inhibits the growth of
diverse cancer cells. We have reported its inhibitory effects on the growth of gastric cancer …

Myelodysplastic syndromes (MDS) are defined as clonal hematopoietic stem‐cell disorders
characterized by ineffective hematopoiesis in one or more of the lineages of the bone …

Cell expansion and metastasis are considered hallmarks of tumour progression. Therefore,
efforts have been made to develop novel anti‐cancer drugs that inhibit both the proliferation …

The standard therapeutic approaches for acute myeloid leukemia (AML) continue to be
based on anthracyclines and cytarabine. However, the prognosis for AML remains poor …

Medulloblastoma is the most common malignant cancer of the central nervous system in
children. AKT kinases are part of a survival pathway that has been found to be significantly …

Barringtonia racemosa has been used as a traditional medicine for the treatment of various
diseases. The antitumor property of the seed extract of this plant in mice model promotes us …

Deregulation of the protein kinase C (PKC) signalling pathway has been implicated in tumor
progression. Here we investigated the PKC inhibitor enzastaurin for its activity against …