Cancer may arise because the developmental programs that create the dramatic alterations
in form and structure in embryonic development are potentially corrupted. The cells in our …

Inflammation is thought to play a role in the pathophysiology of cancer. Accumulating
evidence from clinical and laboratory-based studies suggests that substances with anti …

Nonsteroidal anti-inflammatory drugs (NSAID) display promising antineoplastic activity for
colorectal and other cancers, but toxicity from COX inhibition limits their long-term use for …

β-Catenin plays an important role in development and tumorigenesis. However, the effect of
a key acetyltransferase p300/CBP-associated factor (PCAF) on β-catenin signaling is largely …

Nonselective cyclooxygenase (COX) inhibitors target many of the same cancer-associated
molecular pathways as COX-2–specific inhibitors. Although these nonsteroidal anti …

Inhibition of deregulated protein tyrosine kinases represents an attractive strategy for
controlling cancer growth. However, target specificity is an essential aim of this strategy. In …

Nonsteroidal anti-inflammatory drugs (NSAIDs) have been widely reported to inhibit tumor
growth by a COX-independent mechanism, although alternative targets have not been well …

c-Src is a non-receptor tyrosine kinase whose activity is induced by phosphorylation at Y418
and translocation from the cytoplasm to the cell membrane. Increased activity of c-Src has …

Background Products of the SOX gene family play important roles in the life process. One of
the members, SOX7, is associated with the development of a variety of cancers as a tumor …

Functional activation of β‐catenin/T‐cell factor (Tcf) signaling has been implicated in human
carcinogenesis. We identified the inhibitory effect of various polyphenolic flavonoid …