Discovery and development of calcium channel blockers

T Godfraind - Frontiers in pharmacology, 2017 - frontiersin.org
In the mid 1960s, experimental work on molecules under screening as coronary dilators
allowed the discovery of the mechanism of calcium entry blockade by drugs later named …

ACC/AHA guidelines for the management of patients with acute myocardial infarction: a report of the American College of Cardiology/American Heart Association Task …

TJ Ryan, JL Anderson, EM Antman, BA Braniff… - Journal of the American …, 1996 - Elsevier
The ACC/AHA statement" Guidelines for the Early Management of Patients with Acute
Myocardial Infarction" was introduced in 1990, 1 following a time during which advances in …

ACC/AHA/ACP-ASIM guidelines for the management of patients with chronic stable angina: a report of the American College of Cardiology/American Heart …

RJ Gibbons, K Chatterjee, J Daley, JS Douglas… - Journal of the American …, 1999 - jacc.org
It is important that the medical profession play a significant role in critically evaluating the
use of diagnostic procedures and therapies in the management or prevention of disease …

Effect of long-acting nifedipine on mortality and cardiovascular morbidity in patients with stable angina requiring treatment (ACTION trial): randomised controlled trial

PA Poole-Wilson, J Lubsen, BA Kirwan, FJ van Dalen… - The Lancet, 2004 - thelancet.com
Background Calcium antagonists are widely prescribed for angina pectoris but their effect on
clinical outcome is controversial. We aimed to investigate the effect of the calcium antagonist …

Conflict of interest in the debate over calcium-channel antagonists

HT Stelfox, G Chua, K O'Rourke… - New England Journal of …, 1998 - Mass Medical Soc
Background Physicians' financial relationships with the pharmaceutical industry are
controversial because such relationships may pose a conflict of interest. It is unknown to …

Атеросклероз: патогенез, клиника, функциональная диагностика, лечение

РС Карпов, ВА Дудко - 1998 - elibrary.ru
В книге рассмотрены современные патогенные, патофизиологические, клинические,
инструментальные и терапевтические аспекты атеросклеротического повреждения …

Calcium antagonists

E Grossman, FH Messerli - Progress in Cardiovascular Diseases, 2004 - Elsevier
Calcium antagonists were introduced for the treatment of hypertension in the 1980s. Their
use was subsequently expanded to additional disorders, such as angina pectoris …

Rationale and design of the International Verapamil SR/Trandolapril Study (INVEST): an Internet-based randomized trial in coronary artery disease patients with …

CJ Pepine, E Handberg-Thurmond, RG Marks… - Journal of the American …, 1998 - jacc.org
Objectives. The primary objective of the International Verapamil SR/Trandolapril Study
(INVEST) is to compare the risk for adverse outcomes (all-cause mortality, nonfatal …

Calcium channel blockers in cardiovascular pharmacotherapy

T Godfraind - Journal of cardiovascular pharmacology and …, 2014 - journals.sagepub.com
This paper summarizes the pharmacological properties of calcium channel blockers (CCBs),
their established therapeutic uses for cardiovascular disorders and the current improvement …

Thrombosis in ischemic heart disease

JA Ambrose, M Weinrauch - Archives of internal medicine, 1996 - jamanetwork.com
Thrombus formation on a fissured or disrupted atherosclerotic plaque is the main
pathogenetic mechanism for the acute coronary syndromes of myocardial infarction and …