Malaria has been a major global health problem of humans through history and is a leading
cause of death and disease across many tropical and subtropical countries. Over the last …

Executive summary 50 years after a noble but flawed attempt to eradicate malaria in the mid-
20th century, the global malaria community is once again seriously considering eradication …

“Asymptomatic” Malaria: A Chronic and Debilitating Infection That Should Be Treated | PLOS
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Infectious disease control and prevention relies on a thorough understanding of the factors
determining transmission. This article summarizes the fundamental principles of infectious …

Cerebral malaria is among the major causes of malaria-associated mortality and effective
adjunctive therapeutic strategies are currently lacking. Central pathophysiological processes …

Vaccines work by eliciting an immune response and consequent immunological memory
that mediates protection from infection or disease. Recently, new methods have been …

Costimulatory and inhibitory receptors play a key role in regulating immune responses to
infections. Recent translation of knowledge about inhibitory receptors such as CTLA-4 and …

Synthetic oligonucleotides (ODN) that express unmethylated “CpG motifs” trigger cells that
express Toll-like receptor 9. In humans this includes plasmacytoid dendritic cells and B cells …

Malaria is a mosquito-borne disease caused by parasites of the obligate intracellular
Apicomplexa phylum the most deadly of which, Plasmodium falciparum, prevails in Africa …

Malaria caused by the Plasmodium family of parasites, especially P. falciparum and P. vivax,
is a major health problem in many countries in the tropical and subtropical regions of the …