The pathophysiology of sepsis and precision-medicine-based immunotherapy
EJ Giamarellos-Bourboulis, AC Aschenbrenner… - Nature …, 2024 - nature.com
Sepsis remains a major cause of morbidity and mortality in both low-and high-income
countries. Antibiotic therapy and supportive care have significantly improved survival …
countries. Antibiotic therapy and supportive care have significantly improved survival …
During sepsis and COVID-19, the pro-inflammatory and anti-inflammatory responses are concomitant
JM Cavaillon - Clinical Reviews in Allergy & Immunology, 2023 - Springer
The most severe forms of COVID-19 share many features with bacterial sepsis and have
thus been considered to be a viral sepsis. Innate immunity and inflammation are closely …
thus been considered to be a viral sepsis. Innate immunity and inflammation are closely …
The noncanonical inflammasome-induced pyroptosis and septic shock
Sepsis remains one of the most common and lethal conditions globally. Currently, no
proposed target specific to sepsis improves survival in clinical trials. Thus, an in-depth …
proposed target specific to sepsis improves survival in clinical trials. Thus, an in-depth …
Use of electronic clinical data to track incidence and mortality for SARS-CoV-2–associated sepsis
Importance Efforts to quantify the burden of SARS-CoV-2–associated sepsis have been
limited by inconsistent definitions and underrecognition of viral sepsis. Objective To describe …
limited by inconsistent definitions and underrecognition of viral sepsis. Objective To describe …
[HTML][HTML] S100A8/A9: An emerging player in sepsis and sepsis-induced organ injury
Q Wang, G Long, H Luo, X Zhu, Y Han, Y Shang… - Biomedicine & …, 2023 - Elsevier
Sepsis, the foremost contributor to mortality in intensive care unit patients, arises from an
uncontrolled systemic response to invading infections, resulting in extensive harm across …
uncontrolled systemic response to invading infections, resulting in extensive harm across …
[HTML][HTML] Antimicrobial stewardship using biomarkers: Accumulating evidence for the critically ill
E Kyriazopoulou, EJ Giamarellos-Bourboulis - Antibiotics, 2022 - mdpi.com
This review aims to summarize current progress in the management of critically ill, using
biomarkers as guidance for antimicrobial treatment with a focus on antimicrobial …
biomarkers as guidance for antimicrobial treatment with a focus on antimicrobial …
[HTML][HTML] How sepsis parallels and differs from COVID-19
A Herminghaus, MF Osuchowski - EBioMedicine, 2022 - thelancet.com
A recent meta-analysis 1 indicated that the majority of severely ill COVID-19 patients (78%)
met the Sepsis 3.0 criteria for sepsis/septic shock with acute respiratory distress syndrome …
met the Sepsis 3.0 criteria for sepsis/septic shock with acute respiratory distress syndrome …
[HTML][HTML] Plasma Proprotein Convertase Subtilisin/Kexin type 9 (PCSK9) as a possible biomarker for severe COVID-19
P Mester, P Amend, S Schmid, M Müller, C Buechler… - Viruses, 2023 - mdpi.com
Proprotein convertase subtilisin/kexin type 9 (PCSK9) reduces low density lipoprotein (LDL)
uptake, leading to increased plasma levels of LDL. In addition, PCSK9 has been implicated …
uptake, leading to increased plasma levels of LDL. In addition, PCSK9 has been implicated …
[HTML][HTML] Prevalence, clinical characteristics, and outcomes of sepsis caused by severe acute respiratory syndrome coronavirus 2 versus other pathogens in …
Prevalence, Clinical Characteristics, and Outcomes of Sepsis... : Critical Care Explorations
Prevalence, Clinical Characteristics, and Outcomes of Sepsis Caused by Severe Acute …
Prevalence, Clinical Characteristics, and Outcomes of Sepsis Caused by Severe Acute …
[HTML][HTML] Challenges of assessing the burden of sepsis
C Fleischmann-Struzek, K Rudd - Medizinische Klinik-Intensivmedizin und …, 2023 - Springer
Background Sepsis is one of the most frequent causes of death worldwide, but the recording
of population-based epidemiology is challenging, which is why reliable data on sepsis …
of population-based epidemiology is challenging, which is why reliable data on sepsis …