The pathophysiology of sepsis and precision-medicine-based immunotherapy

EJ Giamarellos-Bourboulis, AC Aschenbrenner… - Nature …, 2024 - nature.com
Sepsis remains a major cause of morbidity and mortality in both low-and high-income
countries. Antibiotic therapy and supportive care have significantly improved survival …

During sepsis and COVID-19, the pro-inflammatory and anti-inflammatory responses are concomitant

JM Cavaillon - Clinical Reviews in Allergy & Immunology, 2023 - Springer
The most severe forms of COVID-19 share many features with bacterial sepsis and have
thus been considered to be a viral sepsis. Innate immunity and inflammation are closely …

The noncanonical inflammasome-induced pyroptosis and septic shock

J Wu, J Cai, Y Tang, B Lu - Seminars in Immunology, 2023 - Elsevier
Sepsis remains one of the most common and lethal conditions globally. Currently, no
proposed target specific to sepsis improves survival in clinical trials. Thus, an in-depth …

Use of electronic clinical data to track incidence and mortality for SARS-CoV-2–associated sepsis

CN Shappell, M Klompas, C Chan, T Chen… - JAMA Network …, 2023 - jamanetwork.com
Importance Efforts to quantify the burden of SARS-CoV-2–associated sepsis have been
limited by inconsistent definitions and underrecognition of viral sepsis. Objective To describe …

[HTML][HTML] S100A8/A9: An emerging player in sepsis and sepsis-induced organ injury

Q Wang, G Long, H Luo, X Zhu, Y Han, Y Shang… - Biomedicine & …, 2023 - Elsevier
Sepsis, the foremost contributor to mortality in intensive care unit patients, arises from an
uncontrolled systemic response to invading infections, resulting in extensive harm across …

[HTML][HTML] Antimicrobial stewardship using biomarkers: Accumulating evidence for the critically ill

E Kyriazopoulou, EJ Giamarellos-Bourboulis - Antibiotics, 2022 - mdpi.com
This review aims to summarize current progress in the management of critically ill, using
biomarkers as guidance for antimicrobial treatment with a focus on antimicrobial …

[HTML][HTML] How sepsis parallels and differs from COVID-19

A Herminghaus, MF Osuchowski - EBioMedicine, 2022 - thelancet.com
A recent meta-analysis 1 indicated that the majority of severely ill COVID-19 patients (78%)
met the Sepsis 3.0 criteria for sepsis/septic shock with acute respiratory distress syndrome …

[HTML][HTML] Plasma Proprotein Convertase Subtilisin/Kexin type 9 (PCSK9) as a possible biomarker for severe COVID-19

P Mester, P Amend, S Schmid, M Müller, C Buechler… - Viruses, 2023 - mdpi.com
Proprotein convertase subtilisin/kexin type 9 (PCSK9) reduces low density lipoprotein (LDL)
uptake, leading to increased plasma levels of LDL. In addition, PCSK9 has been implicated …

[HTML][HTML] Prevalence, clinical characteristics, and outcomes of sepsis caused by severe acute respiratory syndrome coronavirus 2 versus other pathogens in …

CN Shappell, M Klompas, S Kanjilal… - Critical care …, 2022 - journals.lww.com
Prevalence, Clinical Characteristics, and Outcomes of Sepsis... : Critical Care Explorations
Prevalence, Clinical Characteristics, and Outcomes of Sepsis Caused by Severe Acute …

[HTML][HTML] Challenges of assessing the burden of sepsis

C Fleischmann-Struzek, K Rudd - Medizinische Klinik-Intensivmedizin und …, 2023 - Springer
Background Sepsis is one of the most frequent causes of death worldwide, but the recording
of population-based epidemiology is challenging, which is why reliable data on sepsis …