Abstract RAS (KRAS, NRAS and HRAS) is the most frequently mutated gene family in
cancers, and, consequently, investigators have sought an effective RAS inhibitor for more …

Malaria is one of the most devastating infectious diseases of humans. It is problematic
clinically and economically as it prevails in poorer countries and regions, strongly hindering …

SARS-CoV-2, identified in Wuhan, China, for the first time in December 2019, is a new viral
strain, which has not been previously identified in humans; it can be transmitted both by air …

Pancreatic ductal adenocarcinoma (PDA) was responsible for~ 44,000 deaths in the United
States in 2018 and is the epitome of a recalcitrant cancer driven by a pharmacologically …

Background Severe malaria is a major cause of childhood death and often the main reason
for paediatric hospital admission in sub-Saharan Africa. Quinine is still the established …

Quinine remains an important anti-malarial drug almost 400 years after its effectiveness was
first documented. However, its continued use is challenged by its poor tolerability, poor …

Infections have represented for a long time the leading cause of death in humans. During
the 19th century, pneumonia, tuberculosis, diarrhea and diphtheria were considered the …

Infection of erythrocytes with Plasmodium species induces clinical malaria. Parasite-specific
CD4+ T cells correlate with lower parasite burdens and severity of human malaria and are …

Increased efforts in antimalarial drug discovery are urgently needed. The goal must be to
develop safe and affordable new drugs to counter the spread of malaria parasites that are …

Malaria represents a medical emergency because it may rapidly progress to complications
and death without prompt and appropriate treatment. Severe malaria is almost exclusively …