Altered myeloid inflammation and lymphopenia are hallmarks of severe infections. We
identified the upregulated EN-RAGE gene program in airway and blood myeloid cells from …

In the race against COVID-19 for timely therapeutic developments, mass spectrometry-
based high-throughput methods have been valuable. COVID-19 manifests an extremely …

In the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic 1,
considerable focus has been placed on a model of viral entry into host epithelial …

People with diabetes are more likely to have severe COVID-19 compared to the general
population. Moreover, diabetes and COVID-19 demonstrate a certain parallelism in the …

In this issue of eBioMedicine, Dr. McElvaney and colleagues report altered protease/anti-
protease balance in moderate to severe COVID-19 ARDS by the disease processes as well …

Age is a major risk factor for severe coronavirus disease-2019 (COVID-19), yet the
mechanisms responsible for this relationship have remained incompletely understood. To …

Background The entry of the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐
2) into the host cell is carried out by specific receptors and enzymes, including human …

Coronavirus disease 2019 (COVID-19) has infected more than 470 million people and
caused more than 6 million deaths worldwide. The high mortality mainly owes to the …

We appreciate the comments from Dr. Bain and colleagues regarding our recent ATS
workshop report titled “Research Bronchoscopies in Critically Ill Research Participants.”(1) …

Auto-antibodies (Abs) to type I interferons (IFNs) are found in up to 25% of patients with
severe COVID-19, and are implicated in disease pathogenesis. It has remained unknown …