The matrilins form a family of oligomeric extracellular adaptor proteins that are most strongly
expressed in cartilage but also present in many other extracellular matrices. Matrilins bind to …

The extracellular matrix (ECM) of cartilage performs essential functions in differentiation and
chondroprogenitor cell maintenance during development and regeneration. Here, we …

Introduction Deletion or mutation of the gene encoding the cartilage extracellular matrix
(ECM) protein matrilin-3 (MATN3) results in the early onset of osteoarthritis (OA), suggesting …

Isolated chondrocytes form aggregates in suspension culture that maintain chondrocyte
phenotype in a physiological pericellular environment. The molecular mechanisms involved …

During homeostasis, hematopoietic stem cells (HSCs) are mostly kept in quiescence with
only minor contribution to steady-state hematopoiesis. However, in stress situations such as …

Matrilins are adaptor proteins of the extracellular matrix involved in the formation of both
collagen-dependent and collagen-independent filamentous networks. Although their …

The extracellular matrix (ECM) has long been viewed primarily as an organized network of
solid-phase ligands for integrin receptors. During degenerative processes, such as …

Objective To identify regulators of the cartilaginous phenotype, on the basis of their
differential expression in human conventional chondrogenic tumors compared with articular …

Here, we identify a role for the matrilin-2 (Matn2) extracellular matrix protein in controlling
the early stages of myogenic differentiation. We observed Matn2 deposition around …

A homolog of mammalian secretory leucocyte proteinase inhibitor or SLPI known as a
double WAP domain (DWD) protein has been found in penaeid shrimp and believed to play …