Human cytochrome P450 (CYP) enzymes, as membrane-bound hemoproteins, play
important roles in the detoxification of drugs, cellular metabolism, and homeostasis. In …

Drug metabolism is a critical process for the removal of unwanted substances from the body.
In humans, approximately 80% of oxidative metabolism and almost 50% of the overall …

The Organ-on-a-Chip (OoC) technology shows great potential to revolutionize the drugs
development pipeline by mimicking the physiological environment and functions of human …

The lack of effective therapies that slow the progression of Alzheimer's disease (AD) and
related tauopathies highlights the need for a more comprehensive understanding of the …

Due to the aging population in the world, neurodegenerative diseases have become a
serious public health issue that greatly impacts patients' quality of life and adds a huge …

Arsenic is well-recognized as one of the most hazardous elements which is characterized by
its omnipresence throughout the environment in various chemical forms. From the simple …

Aging is associated to cognitive decline, which can lead to loss of life quality, personal
suffering, and ultimately neurodegenerative diseases. Neuroinflammation is one of the …

Cytochrome P450 and other families of drug-metabolizing enzymes are commonly thought
of and studied for their ability to metabolize xenobiotics and other foreign entities as they are …

Metalloenzymes are responsible for numerous physiological and pathological processes in
living organisms; however, there are very few FDA-approved metalloenzyme-targeting …

The current state of knowledge indicates that the cerebral cytochrome P450 (CYP) plays an
important role in the endogenous metabolism in the brain. Different CYP isoenzymes …