The symbiotic bacteria that live in the human gut and the metabolites they produce have
long influenced local and systemic physiological and pathological processes of the host …

The programmed cell death machinery exhibits surprising flexibility, capable of crosstalk and
non-apoptotic roles. Much of this complexity arises from the diverse functions of caspase-8 …

Atherosclerosis, a chronic inflammatory disease characterized by arterial plaque
accumulation, remains a significant global health challenge. In recent years …

Abstract Ethnopharmacological relevance Modified Simiaowan (MSM) is a six-herb formula
that has been shown to be effective in gouty arthritis (GA) has been proven, but its regulatory …

Inflammasomes are important modulators of inflammation. Dysregulation of inflammasomes
can enhance vulnerability to conditions such as neurodegenerative diseases …

Inflammasomes are multiprotein complexes, which are assembled in response to a diverse
range of exogenous pathogens and endogenous danger signals, leading to produce pro …

Pyroptosis is a regulated form of cell death that leads to inflammation and plays a role in
many different diseases. Pyroptosis was initially defined by the dependence on caspase-1, a …

Inflammation is a natural reaction of the innate immune system that evolved primarily to
protect the human body from invading pathogens and to heal injuries. There are two …

Pyroptosis defines a form of pro-inflammatory-dependent programmed cell death triggered
by gasdermin proteins, which creates cytoplasmic pores and promotes the activation and …

Dehydrocurvularin (DCV) is a natural-product macrolide that has been shown to exert anti-
inflammatory activity. However, the underlying mechanism of its anti-inflammatory activity …