Migraine is a severe neurovascular disorder of which the pathophysiology is not yet fully
understood. Besides the role of inflammatory mediators that interact with the …

A broad group of antiepileptic drugs (AEDs) often controls the frequency of seizures. Given
the variability of pharmacokinetics, narrow target range, and the difficulty of identifying signs …

The main strategy for the treatment of epilepsy is the use of pharmacological agents known
as antiseizure medication (ASM). These drugs control the seizure onset and improves the …

Objective Poor medication adherence remains a concern for individuals managing their
epilepsy with antiseizure medicines (ASMs); however, ethical concerns around withholding …

N-type voltage-gated calcium channel controls the release of neurotransmitters from
neurons. The association of other voltage-gated calcium channels with epilepsy is well …

Objective Cenobamate is an antiseizure medication (ASM) associated with high rates of
seizure freedom and acceptable tolerability in patients with focal seizures. To achieve the …

Objective Cenobamate was approved by the US Food and Drug Administration (FDA) based
on studies of adjunctive therapy in patients with focal epilepsy. To support the use of …

Objective: This study aims to compare the effectiveness and safety of perampanel and
oxcarbazepine as monotherapy in children with focal epilepsy (FE). Methods: This is an …

Introduction Despite the availability of around 30 antiseizure medications, 1/3 of patients
with epilepsy fail to become seizure-free upon pharmacological treatment. Available …

Therapeutic drug monitoring is useful for individual dosage adjustment and avoiding drug
toxicity for certain drugs with narrow therapeutic window. However, only relatively few drugs …