[HTML][HTML] Current status of human papillomavirus-related head and neck cancer: from viral genome to patient care

H Dong, X Shu, Q Xu, C Zhu, AM Kaufmann, ZM Zheng… - Virologica Sinica, 2021 - Springer
Human papillomavirus (HPV) infection identified as a definitive human carcinogen is
increasingly being recognized for its role in carcinogenesis of human cancers. Up to 38 …

Human papillomavirus genome integration in squamous carcinogenesis: what have next‐generation sequencing studies taught us?

IJ Groves, N Coleman - The Journal of pathology, 2018 - Wiley Online Library
Human papillomavirus (HPV) infection is associated with∼ 5% of all human cancers,
including a range of squamous cell carcinomas. Persistent infection by high‐risk HPVs …

[HTML][HTML] Meta analysis: HPV and p16 pattern determines survival in patients with HNSCC and identifies potential new biologic subtype

AE Albers, X Qian, AM Kaufmann, A Coordes - Scientific reports, 2017 - nature.com
Consistent discrepancies in the p16/HPV-positivity have been observed in head and neck
squamous cell carcinoma (HNSCC). It is therefore questionable, if all HPV+ and/or p16+ …

Multi‐omics data reveals novel impacts of human papillomavirus integration on the epigenomic and transcriptomic signatures of cervical tumorigenesis

X Zeng, Y Wang, B Liu, X Rao, C Cao… - Journal of Medical …, 2023 - Wiley Online Library
Integration of human papilloma virus (HPV) DNA into the human genome may progressively
contribute to cervical carcinogenesis. To explore how HPV integration affects gene …

[HTML][HTML] Short- and long-range cis interactions between integrated HPV genomes and cellular chromatin dysregulate host gene expression in early cervical …

IJ Groves, ELA Drane, M Michalski, JM Monahan… - PLoS …, 2021 - journals.plos.org
Development of cervical cancer is directly associated with integration of human
papillomavirus (HPV) genomes into host chromosomes and subsequent modulation of HPV …

[HTML][HTML] Causes and consequences of HPV integration in head and neck squamous cell carcinomas: state of the art

H Balaji, I Demers, N Wuerdemann, J Schrijnder… - Cancers, 2021 - mdpi.com
Simple Summary In human papillomavirus (HPV) associated head and neck squamous cell
carcinomas (HNSCC) s, the HPV genome is commonly found integrated in the human …

[HTML][HTML] Novel insights into epigenetic drivers of oropharyngeal squamous cell carcinoma: role of HPV and lifestyle factors

P Boscolo-Rizzo, C Furlan, V Lupato, J Polesel… - Clinical …, 2017 - Springer
In the last years, the explosion of high throughput sequencing technologies has enabled
epigenome-wide analyses, allowing a more comprehensive overview of the oropharyngeal …

ViMIC: a database of human disease-related virus mutations, integration sites and cis-effects

Y Wang, Y Tong, Z Zhang, R Zheng… - Nucleic Acids …, 2022 - academic.oup.com
Molecular mechanisms of virus-related diseases involve multiple factors, including viral
mutation accumulation and integration of a viral genome into the host DNA. With increasing …

Identification of transcriptionally‐active human papillomavirus integrants through nanopore sequencing reveals viable targets for gene therapy against cervical cancer

Q Zhao, S Yang, S Hao, Z Chen, L Tang… - Journal of Medical …, 2024 - Wiley Online Library
Integration of the human papillomavirus (HPV) genome into the cellular genome is a key
event that leads to constitutive expression of viral oncoprotein E6/E7 and drives the …

[HTML][HTML] Methyltransferase G9a promotes cervical cancer angiogenesis and decreases patient survival

RJ Chen, CT Shun, ML Yen, CH Chou, MC Lin - Oncotarget, 2017 - ncbi.nlm.nih.gov
Research suggests that the epigenetic regulator G9a, a H3K9 histone methyltransferase, is
involved in cancer invasion and metastasis. Here we show that G9a is linked to cancer …