The mechanisms by which cells sense their mechanical environment and transduce the
signal through focal adhesions and signaling pathways to the nucleus is an area of key …

The expansion of adipose tissue is an adaptive mechanism that increases nutrient buffering
capacity in response to an overall positive energy balance. Over the course of expansion …

Reprogramming of amino acid metabolism, sustained by oncogenic signaling, is crucial for
cancer cell survival under nutrient limitation. Here we discovered that missense mutant p53 …

Flow cytometry is used routinely to measure single-cell gene expression by staining cells
with fluorescent antibodies and nucleic acids. Here, we present tension-activated cell …

Cell function relies on the spatiotemporal dynamics of metabolic reactions. In all
physiopathological processes of tissues, mechanical forces impact the structure and function …

Metabolism and mechanics are two key facets of structural and functional processes in cells,
such as growth, proliferation, homeostasis and regeneration. Their reciprocal regulation has …

Perivascular collagen deposition by activated fibroblasts promotes vascular stiffening and
drives cardiovascular diseases such as pulmonary hypertension (PH). Whether and how …

Recent advances in biomaterials and 3D printing/culture methods enable various tissue-
engineered tumor models. However, it is still challenging to achieve native tumor-like …

Biomolecular condensates regulate a wide range of cellular functions from signaling to RNA
metabolism1, 2, yet, the physiologic conditions regulating their formation remain largely …

Mechanotransduction converts physical energy from the extracellular matrix (ECM) or the
surrounding physical cues into the biochemical stimulus that drives several biological …