Highlights•Innate mesenchymal-stroma maintains a tumor-suppressive homeostatic
equilibrium.•Fibroblastic-ECM interplay is referred to as stromal dynamic reciprocity.• …

Pancreatic cancer is one of the most lethal types of cancer in the world. The incidence of
pancreatic cancer increases each year with no significant decrease in mortality. Pancreatic …

Simple Summary Pancreatic ductal adenocarcinoma is a devastating disease that is very
hard to treat. Here, we advance and evaluate the notion that the best possible management …

The tumor microenvironment (TME) is a complex neighborhood that consists of immune
cells, fibroblasts, pericytes, adipocytes, endothelial and neuronal cells, and the extracellular …

Pancreatic cancer is currently the fourth leading cause of cancer-related death, and it is
projected that within the next two decades it will become the second most common cause of …

Pancreatic cancer stem cells (CSCs) have been first described in 2007 and since then have
emerged as an intriguing entity of cancer cells with distinct functional features including self …

Background Pancreatic ductal adenocarcinoma (PDAC) patients suffer poor outcomes,
including a five-year survival of below 10%. Poor outcomes result in part from therapeutic …

The consumption of vitamins C and D for prevention and treatment of cancer is still an
uncertain recommendation due to their controversial roles in cancer. The epidemiological …

Introduction: Decades of efforts have yet to yield a safe and effective drug to target KRAS-
driven pancreatic, colorectal and lung cancers; particularly those driven by the highly …

The diverse effects of 1, 25-dihydroxyvitamin D3 (1, 25 (OH) 2D3), the bio-active form of
vitamin D, on cancer cell metabolism and proliferation has made it an interesting candidate …