Scientific evidence collected over the past 4 decades suggests that a loss of cholinergic
innervation in the cerebral cortex of patients with Alzheimer's disease is an early pathogenic …

Age-related cognitive changes often include difficulties in retrieving memories, particularly
those that rely on personal experiences within their temporal and spatial contexts (ie …

Chlorogenic acid is a major polyphenolic component of many plants and beverages, and is
particularly abundant in coffee. We evaluated the neuroprotective effects of chlorogenic acid …

Background: Galantamine is a reversible, competitive cholinesterase inhibitor that also
allosterically modulates nicotinic acetylcholine receptors. These mechanisms of action …

In traditional practices of Ayurvedic and Chinese medicine, numerous plants have been
used to treat cognitive disorders, including neurodegenerative diseases such as Alzheimer's …

In traditional practices of medicine, numerous plants have been used to treat cognitive
disorders, including neurodegenerative diseases such as Alzheimer's disease (AD) and …

Apigenin has gained particular interests in recent years as a beneficial and health promoting
agent because of its low intrinsic toxicity. Vitexin and isovitexin, naturally occurring C …

The current drug treatment for Alzheimer's disease (AD) is only partially and temporary
effective. Transcranial magnetic stimulation (TMS) is a non-invasive technique that …

Breakdown of cellular membranes is a characteristic feature of neuronal degeneration in
acute (stroke) and chronic (senile dementia) neurological disorders. The present review …

Deficits in cholinergic function contribute to the pathology of Alzheimer's disease (AD),
affecting cognition, behaviour and activities of daily living. Pharmacological intervention …