Revisiting the cholinergic hypothesis in Alzheimer's disease: emerging evidence from translational and clinical research
Scientific evidence collected over the past 4 decades suggests that a loss of cholinergic
innervation in the cerebral cortex of patients with Alzheimer's disease is an early pathogenic …
innervation in the cerebral cortex of patients with Alzheimer's disease is an early pathogenic …
Episodic memory in normal aging and Alzheimer disease: Insights from imaging and behavioral studies
D Tromp, A Dufour, S Lithfous, T Pebayle… - Ageing research …, 2015 - Elsevier
Age-related cognitive changes often include difficulties in retrieving memories, particularly
those that rely on personal experiences within their temporal and spatial contexts (ie …
those that rely on personal experiences within their temporal and spatial contexts (ie …
Neuroprotective effects of chlorogenic acid on scopolamine-induced amnesia via anti-acetylcholinesterase and anti-oxidative activities in mice
Chlorogenic acid is a major polyphenolic component of many plants and beverages, and is
particularly abundant in coffee. We evaluated the neuroprotective effects of chlorogenic acid …
particularly abundant in coffee. We evaluated the neuroprotective effects of chlorogenic acid …
Galantamine in AD: a 6-month randomized, placebo-controlled trial with a 6-month extension
MA Raskind, ER Peskind, T Wessel, W Yuan… - Neurology, 2000 - AAN Enterprises
Background: Galantamine is a reversible, competitive cholinesterase inhibitor that also
allosterically modulates nicotinic acetylcholine receptors. These mechanisms of action …
allosterically modulates nicotinic acetylcholine receptors. These mechanisms of action …
Plants used in Chinese and Indian traditional medicine for improvement of memory and cognitive function
MJR Howes, PJ Houghton - Pharmacology Biochemistry and Behavior, 2003 - Elsevier
In traditional practices of Ayurvedic and Chinese medicine, numerous plants have been
used to treat cognitive disorders, including neurodegenerative diseases such as Alzheimer's …
used to treat cognitive disorders, including neurodegenerative diseases such as Alzheimer's …
Plants with traditional uses and activities, relevant to the management of Alzheimer's disease and other cognitive disorders
MJR Howes, NSL Perry… - Phytotherapy research: An …, 2003 - Wiley Online Library
In traditional practices of medicine, numerous plants have been used to treat cognitive
disorders, including neurodegenerative diseases such as Alzheimer's disease (AD) and …
disorders, including neurodegenerative diseases such as Alzheimer's disease (AD) and …
Effects of C-glycosylation on anti-diabetic, anti-Alzheimer's disease and anti-inflammatory potential of apigenin
Apigenin has gained particular interests in recent years as a beneficial and health promoting
agent because of its low intrinsic toxicity. Vitexin and isovitexin, naturally occurring C …
agent because of its low intrinsic toxicity. Vitexin and isovitexin, naturally occurring C …
Beneficial effect of repetitive transcranial magnetic stimulation combined with cognitive training for the treatment of Alzheimer's disease: a proof of concept study
J Bentwich, E Dobronevsky, S Aichenbaum… - Journal of neural …, 2011 - Springer
The current drug treatment for Alzheimer's disease (AD) is only partially and temporary
effective. Transcranial magnetic stimulation (TMS) is a non-invasive technique that …
effective. Transcranial magnetic stimulation (TMS) is a non-invasive technique that …
Membrane breakdown in acute and chronic neurodegeneration: focus on choline-containing phospholipids
J Klein - Journal of neural transmission, 2000 - Springer
Breakdown of cellular membranes is a characteristic feature of neuronal degeneration in
acute (stroke) and chronic (senile dementia) neurological disorders. The present review …
acute (stroke) and chronic (senile dementia) neurological disorders. The present review …
Cholinergic function and Alzheimer's disease
E Giacobini - International journal of geriatric psychiatry, 2003 - Wiley Online Library
Deficits in cholinergic function contribute to the pathology of Alzheimer's disease (AD),
affecting cognition, behaviour and activities of daily living. Pharmacological intervention …
affecting cognition, behaviour and activities of daily living. Pharmacological intervention …