[HTML][HTML] Pro-resolving lipid mediators: regulators of inflammation, metabolism and kidney function
Obesity, diabetes mellitus, hypertension and cardiovascular disease are risk factors for
chronic kidney disease (CKD) and kidney failure. Chronic, low-grade inflammation is …
chronic kidney disease (CKD) and kidney failure. Chronic, low-grade inflammation is …
Structural elucidation and physiologic functions of specialized pro-resolving mediators and their receptors
The acute inflammatory response is host-protective to contain foreign invaders. Many of
today's pharmacopeia that block pro-inflammatory chemical mediators can cause serious …
today's pharmacopeia that block pro-inflammatory chemical mediators can cause serious …
Resolvin D1 activates the inflammation resolving response at splenic and ventricular site following myocardial infarction leading to improved ventricular function
Unresolved inflammation is a major contributor to the development of heart failure following
myocardial infarction (MI). Pro-resolving lipid mediators, such as resolvins (eg RvD1), are …
myocardial infarction (MI). Pro-resolving lipid mediators, such as resolvins (eg RvD1), are …
Resolvins and cysteinyl-containing pro-resolving mediators activate resolution of infectious inflammation and tissue regeneration
This review is a synopsis of the main points from the opening presentation by the authors in
the Resolution of Inflammation session at the 8th European Workshop on Lipid Mediators …
the Resolution of Inflammation session at the 8th European Workshop on Lipid Mediators …
[HTML][HTML] Therapeutic potential of pro-resolving mediators in diabetic kidney disease
Renal microvascular disease associated with diabetes [Diabetic kidney disease-DKD] is the
leading cause of chronic kidney disease. In DKD, glomerular basement membrane …
leading cause of chronic kidney disease. In DKD, glomerular basement membrane …
[HTML][HTML] Roles of resolvins in chronic inflammatory response
C Liu, D Fan, Q Lei, A Lu, X He - International journal of molecular …, 2022 - mdpi.com
An inflammatory response is beneficial to the organism, while an excessive uncontrolled
inflammatory response can lead to the nonspecific killing of tissue cells. Therefore …
inflammatory response can lead to the nonspecific killing of tissue cells. Therefore …
[HTML][HTML] Recent advances in the design and development of formyl peptide receptor 2 (FPR2/ALX) agonists as pro-resolving agents with diverse therapeutic potential
Under physiological conditions the initiation, duration and amplitude of inflammatory
responses are tightly regulated to ensure the restoration of homeostasis. The resolution of …
responses are tightly regulated to ensure the restoration of homeostasis. The resolution of …
[HTML][HTML] Untargeted plasma metabolomics identifies endogenous metabolite with drug-like properties in chronic animal model of multiple sclerosis
We performed untargeted metabolomics in plasma of B6 mice with experimental
autoimmune encephalitis (EAE) at the chronic phase of the disease in search of an altered …
autoimmune encephalitis (EAE) at the chronic phase of the disease in search of an altered …
[HTML][HTML] Resolvin D1 supports skeletal myofiber regeneration via actions on myeloid and muscle stem cells
Specialized proresolving mediators (SPMs) actively limit inflammation and expedite its
resolution by modulating leukocyte recruitment and function. Here we profiled intramuscular …
resolution by modulating leukocyte recruitment and function. Here we profiled intramuscular …
[HTML][HTML] Molecular pharmacology of inflammation resolution in atherosclerosis
S Kotlyarov, A Kotlyarova - International Journal of Molecular Sciences, 2022 - mdpi.com
Atherosclerosis is one of the most important problems of modern medicine as it is the
leading cause of hospitalizations, disability, and mortality. The key role in the development …
leading cause of hospitalizations, disability, and mortality. The key role in the development …