The intramembrane protease γ-secretase is a hetero-tetrameric protein complex with
presenilin as the catalytic subunit and cleaves its membrane protein substrates within their …

A compelling long-term goal of cancer biology is to understand the crucial players during
tumorigenesis in order to develop new interventions. Here, we review how the four non …

Notch signaling is evolutionarily conserved and operates in many cell types and at various
stages during development. Notch signaling must therefore be able to generate appropriate …

The Notch signalling pathway is evolutionarily conserved and is crucial for the development
and homeostasis of most tissues. Deregulated Notch signalling leads to various diseases …

The discovery of Notch in Drosophila melanogaster nearly a century ago opened the door to
an ever-widening understanding of cellular processes that are controlled or influenced by …

Notch signaling regulates many aspects of metazoan development and tissue renewal.
Accordingly, the misregulation or loss of Notch signaling underlies a wide range of human …

Since Notch phenotypes in Drosophila melanogaster were first identified 100 years ago,
Notch signaling has been extensively characterized as a regulator of cell-fate decisions in a …

The Notch pathway is a highly conserved signaling system that controls a diversity of growth,
differentiation, and patterning processes. In growing blood vessels, sprouting of endothelial …

The Alzheimer's disease (AD)-associated amyloid-β protein precursor (AβPP) is cleaved by
α-, β-, and presenilin (PS)/γ-secretases through sequential regulated proteolysis. These …

Notch signaling controls numerous cell-fate specification events in multicellular organisms,
and dysregulated Notch signaling causes several diseases with underlying developmental …