The substrate repertoire of γ-secretase/presenilin
G Güner, SF Lichtenthaler - Seminars in cell & developmental biology, 2020 - Elsevier
The intramembrane protease γ-secretase is a hetero-tetrameric protein complex with
presenilin as the catalytic subunit and cleaves its membrane protein substrates within their …
presenilin as the catalytic subunit and cleaves its membrane protein substrates within their …
TIMPs: versatile extracellular regulators in cancer
HW Jackson, V Defamie, P Waterhouse… - Nature Reviews …, 2017 - nature.com
A compelling long-term goal of cancer biology is to understand the crucial players during
tumorigenesis in order to develop new interventions. Here, we review how the four non …
tumorigenesis in order to develop new interventions. Here, we review how the four non …
Notch signaling: simplicity in design, versatility in function
Notch signaling is evolutionarily conserved and operates in many cell types and at various
stages during development. Notch signaling must therefore be able to generate appropriate …
stages during development. Notch signaling must therefore be able to generate appropriate …
Therapeutic modulation of Notch signalling—are we there yet?
ER Andersson, U Lendahl - Nature reviews Drug discovery, 2014 - nature.com
The Notch signalling pathway is evolutionarily conserved and is crucial for the development
and homeostasis of most tissues. Deregulated Notch signalling leads to various diseases …
and homeostasis of most tissues. Deregulated Notch signalling leads to various diseases …
Notch signalling in solid tumours: a little bit of everything but not all the time
P Ranganathan, KL Weaver, AJ Capobianco - Nature Reviews Cancer, 2011 - nature.com
The discovery of Notch in Drosophila melanogaster nearly a century ago opened the door to
an ever-widening understanding of cellular processes that are controlled or influenced by …
an ever-widening understanding of cellular processes that are controlled or influenced by …
[HTML][HTML] The canonical Notch signaling pathway: unfolding the activation mechanism
R Kopan, MXG Ilagan - Cell, 2009 - cell.com
Notch signaling regulates many aspects of metazoan development and tissue renewal.
Accordingly, the misregulation or loss of Notch signaling underlies a wide range of human …
Accordingly, the misregulation or loss of Notch signaling underlies a wide range of human …
From fly wings to targeted cancer therapies: a centennial for notch signaling
Since Notch phenotypes in Drosophila melanogaster were first identified 100 years ago,
Notch signaling has been extensively characterized as a regulator of cell-fate decisions in a …
Notch signaling has been extensively characterized as a regulator of cell-fate decisions in a …
[HTML][HTML] The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis
R Benedito, C Roca, I Sörensen, S Adams, A Gossler… - Cell, 2009 - cell.com
The Notch pathway is a highly conserved signaling system that controls a diversity of growth,
differentiation, and patterning processes. In growing blood vessels, sprouting of endothelial …
differentiation, and patterning processes. In growing blood vessels, sprouting of endothelial …
The many substrates of presenilin/γ-secretase
A Haapasalo, DM Kovacs - Journal of Alzheimer's disease, 2011 - content.iospress.com
The Alzheimer's disease (AD)-associated amyloid-β protein precursor (AβPP) is cleaved by
α-, β-, and presenilin (PS)/γ-secretases through sequential regulated proteolysis. These …
α-, β-, and presenilin (PS)/γ-secretases through sequential regulated proteolysis. These …
Notch signaling: the core pathway and its posttranslational regulation
ME Fortini - Developmental cell, 2009 - cell.com
Notch signaling controls numerous cell-fate specification events in multicellular organisms,
and dysregulated Notch signaling causes several diseases with underlying developmental …
and dysregulated Notch signaling causes several diseases with underlying developmental …