Research in the development of ophthalmic drug formulations and innovative technologies
over the past few decades has been directed at improving the penetration of medications …

Anatomy and physiology of the eye makes it a highly protected organ. Designing an effective
therapy for ocular diseases, especially for the posterior segment, has been considered as a …

Dilutable nanoemulsions are potent drug delivery vehicles for ophthalmic use due to their
numerous advantages as sustained effect and high ability of drug penetration into the …

purpose. The objective of the present study was to evaluate the therapeutic efficacy of ciliary
neurotrophic factor (CNTF) delivered through encapsulated cells directly into the vitreous of …

Reduction of intraocular pressure (IOP) by pharmaceutical or surgical means has long been
the standard treatment for glaucoma. A number of excellent drugs are available that are …

Introduction Glaucoma is a group of progressive optic neuropathies resulting in irreversible
blindness. It is associated with an elevation of intraocular pressure (> 21 mm Hg) and optic …

Aqueous humour (AH) is an important intraocular fluid responsible for the supply of nutrients
to and removal of metabolic wastes from the avascular tissues of the eye. It is also …

Purpose.: In this work, we tested the hypothesis that highly targeted delivery of antiglaucoma
drugs to the supraciliary space by using a hollow microneedle allows dramatic dose sparing …

Poor drug penetration and rapid clearance after topical instillation of a drug formulation into
the eyes are the major causes for the lower ocular bioavailability from conventional eye …

Background: Several in situ gel-forming systems have been developed to prolong the
precorneal residence time of a drug and to improve ocular bioavailability. Poloxamer 407 …