Injury to or disease of the nervous system can invoke chronic and sometimes intractable
neuropathic pain. Many parallel, interdependent, and time-dependent processes, including …

Opioids are the most commonly used and effective analgesic treatments for severe pain, but
they have recently come under scrutiny owing to epidemic levels of abuse and overdose …

Single-cell RNA sequencing data can unveil the molecular diversity of cell types. Cell type
atlases of the mouse spinal cord have been published in recent years but have not been …

Stimuli that elicit itch are detected by sensory neurons that innervate the skin. This
information is processed by the spinal cord; however, the way in which this occurs is still …

The dorsal horns of the spinal cord and the trigeminal nuclei in the brainstem contain neuron
populations that are critical to process sensory information. Neurons in these areas are …

Pain is a percept of critical importance to our daily survival. In most cases, it serves both an
adaptive function by helping us respond appropriately in a potentially hostile environment …

Somatosensory information is processed by a complex network of interneurons in the spinal
dorsal horn. It has been reported that inhibitory interneurons that express neuropeptide Y …

The ability to sense and move within an environment are complex functions necessary for
the survival of nearly all species. The spinal cord is both the initial entry site for peripheral …

Highlights•Single cell sequencing is elucidating neuronal heterogeneity within sensory
circuits.•Transcriptome, morphology, physiology, and connectome underlie functional cell …

Morphine-induced itch is a very common and debilitating side effect that occurs in laboring
women who receive epidural analgesia and in patients who receive spinal morphine for …