Chronic obstructive pulmonary disease (COPD) is a heterogeneous syndrome associated
with abnormal inflammatory immune responses of the lung to noxious particles and gases …

Glucocorticoids are the most effective anti‐inflammatory therapy for asthma yet are relatively
ineffective in chronic obstructive pulmonary disease. Glucocorticoids suppress inflammation …

Rationale: Patients with asthma exhibit variable response to inhaled corticosteroids (ICS).
Vitamin D is hypothesized to exert effects on phenotype and glucocorticoid (GC) response in …

Cigarette smoking (CS) can impact the immune system and induce pulmonary disorders
such as chronic obstructive pulmonary disease (COPD), which is currently the fourth leading …

Inhaled corticosteroids (ICS) are the most effective controllers of asthma. They suppress
inflammation mainly by switching off multiple activated inflammatory genes through …

Glucocorticoids (GCs) represent the mainstay of current anti‐inflammatory and
immunosuppressive strategies, mediating effects that mostly result in transcriptional …

Children who are referred to specialist care with asthma that does not respond to treatment
(problematic severe asthma) are a heterogeneous group, with substantial morbidity. The …

While the pharmacological management of chronic obstructive pulmonary disease (COPD)
has evolved from the drugs used to treat asthma, the treatment models are different and the …

Background TH 17 cells are proposed to play a role in the pathology of asthma, including
steroid-resistant (SR) disease. We previously identified a steroid-enhancing function of …

There is growing evidence that prenatal adversities could be implicated in foetal
programming of adult chronic diseases. Since maternal stress is known to disturb the foetal …