Calcium signaling plays an important role in gene expression. At the transcriptional level,
this may underpin mammalian neuronal synaptic plasticity. Calcium influx into the …

The starting point, in Marfan syndrome (MFS) appears to be the mutation of fi brillin-1 gene
whose deconstructed protein product cannot bind transforming growth factor beta (TGF-b) …

Patients with Marfan syndrome (MFS) develop thoracic aortic aneurysms as the aorta
presents excessive elastin breaks, fibrosis, and vascular smooth muscle cell (vSMC) death …

Quantitative genetic epistasis has been hypothesized to be an important factor in the
development and progression of complex diseases. Cancers in particular are driven by the …

Objective—Marfan syndrome (MFS) is a connective tissue disorder caused by mutations in
the fibrillin-1 gene. Patients with MFS are at risk of aortic aneurysm formation and dissection …

An emerging paradigm in soil science suggests microbes can perform 'N mining'from
recalcitrant soil organic matter (SOM) in conditions of low N availability. However, this …

In multicellular organisms, the cells are surrounded by persistent, dynamic extracellular
matrix (ECM), the largest calcium reservoir in animals. ECM regulates several aspects of cell …

Pulmonary air leak is the most common complication of lung surgery, contributing to post‐
operative morbidity in up to 60% of patients; yet, there is no reliable treatment. Available …

Fibrillin‐1, the major component of extracellular microfibrils that associate with insoluble
elastin in elastic fibres, is mainly synthesized during development and postnatal growth and …

The aim of this study was to immunolocalise type VI collagen and perlecan and determine
their interactive properties in the intervertebral disc (IVD). Confocal laser scanning …