Overcoming ABC transporter-mediated multidrug resistance: Molecular mechanisms and novel therapeutic drug strategies
Multidrug resistance is a key determinant of cancer chemotherapy failure. One of the major
causes of multidrug resistance is the enhanced efflux of drugs by membrane ABC …
causes of multidrug resistance is the enhanced efflux of drugs by membrane ABC …
Strategies for transporting nanoparticles across the blood–brain barrier
The existence of blood–brain barrier (BBB) hampers the effective treatment of central
nervous system (CNS) diseases. Almost all macromolecular drugs and more than 98% of …
nervous system (CNS) diseases. Almost all macromolecular drugs and more than 98% of …
Mild photothermal therapy potentiates anti-PD-L1 treatment for immunologically cold tumors via an all-in-one and all-in-control strategy
L Huang, Y Li, Y Du, Y Zhang, X Wang, Y Ding… - Nature …, 2019 - nature.com
One of the main challenges for immune checkpoint blockade antibodies lies in malignancies
with limited T-cell responses or immunologically “cold” tumors. Inspired by the capability of …
with limited T-cell responses or immunologically “cold” tumors. Inspired by the capability of …
Functional exosome-mimic for delivery of siRNA to cancer: in vitro and in vivo evaluation
Exosomes, the smallest subgroup of extracellular vesicles, have been recognized as
extracellular organelles that contain genetic and proteomic information for long distance …
extracellular organelles that contain genetic and proteomic information for long distance …
Visible light-induced crosslinking and physiological stabilization of diselenide-rich nanoparticles for redox-responsive drug release and combination chemotherapy
S Zhai, X Hu, Y Hu, B Wu, D Xing - Biomaterials, 2017 - Elsevier
Undesired physiological instability of nanocarriers and premature drug leakage during
blood circulation result in compromised therapeutic efficacy and severe side effects, which …
blood circulation result in compromised therapeutic efficacy and severe side effects, which …
A combination of selenium and polysaccharides: Promising therapeutic potential
J Li, B Shen, S Nie, Z Duan, K Chen - Carbohydrate polymers, 2019 - Elsevier
Currently, selenium and polysaccharide combinations can be identified as three forms:
natural selenium polysaccharides, synthetic selenium polysaccharides and selenium …
natural selenium polysaccharides, synthetic selenium polysaccharides and selenium …
Engineering functional inorganic–organic hybrid systems: advances in siRNA therapeutics
Cancer treatment still faces a lot of obstacles such as tumor heterogeneity, drug resistance
and systemic toxicities. Beyond the traditional treatment modalities, exploitation of RNA …
and systemic toxicities. Beyond the traditional treatment modalities, exploitation of RNA …
Multifunctional nanoparticles: recent progress in cancer therapeutics
Although much progress has been made in treating cancers, cancer death rates in and
around the United States are still high. Current treatments are either ineffective against some …
around the United States are still high. Current treatments are either ineffective against some …
Survivin as a novel target protein for reducing the proliferation of cancer cells
Survivin, also known as baculoviral inhibitor of apoptosis repeat‑containing 5, is a novel
member of the inhibitor of apoptosis protein family. Survivin is highly expressed in tumors …
member of the inhibitor of apoptosis protein family. Survivin is highly expressed in tumors …
Delivery of triptolide: a combination of traditional Chinese medicine and nanomedicine
As a natural product with various biological activities, triptolide (TP) has been reported in
anti-inflammatory, anti-tumor and anti-autoimmune studies. However, the narrow therapeutic …
anti-inflammatory, anti-tumor and anti-autoimmune studies. However, the narrow therapeutic …