Plaque psoriasis is a common, chronic, systemic, immune-mediated inflammatory disease.
The Janus kinase-signal transducer and activator of transcription pathway plays a major role …

We have shown previously that T cells are required for the full development of angiotensin II–
induced hypertension. However, the specific subsets of T cells that are important in this …

Psoriasis, a papulosquamous skin disease, was originally thought of as a disorder primarily
of epidermal keratinocytes, but is now recognised as one of the commonest immune …

Background Interleukins 12 and 23 have important roles in the pathophysiology of psoriasis.
We assessed ustekinumab, a human monoclonal antibody directed against these cytokines …

Psoriasis is a common, chronic, inflammatory, multisystem disease with predominantly skin
and joint manifestations affecting approximately 2% of the population. In this first of 5 …

ContextPsoriasis is the most common T-helper cell type 1 (TH1) immunological disease.
Evidence has linked TH1 diseases to myocardial infarction (MI). Psoriasis has been …

Background Ustekinumab, a human monoclonal antibody against interleukins 12 and 23,
has shown therapeutic potential for psoriasis. This study assessed the efficacy and safety of …

Aims Psoriasis is a common chronic inflammatory T-helper cell-1/17 mediated skin disease.
Recent studies suggest that psoriasis, particularly if severe, may be an independent risk …

Interleukin 17A (IL-17A) is one of the currently known six members of the IL-17 cytokine
family and is implicated in immune responses to infectious pathogens and in the …

Psoriasis is a systemic, immune‐mediated disorder, characterized by inflammatory skin and
joint manifestations. A range of co‐morbidities is associated with psoriasis, including …