Key elements of cancer progression towards metastasis are the biological actions of cancer
stem cells and stromal cells in the tumour microenvironment. Cross-communication between …

TGF-β induces senescence in embryonic tissues. Whether TGF-β in the hypoxic tumor
microenvironment (TME) induces senescence in cancer and how the ensuing senescence …

Notch1 transactivates Notch3 to drive terminal differentiation in stratified squamous
epithelia. Notch1 and other Notch receptor paralogs cooperate to act as a tumor suppressor …

Tumor‐associated neutrophils (TANs) play a crucial role in tumor development and
progression in the cancer microenvironment. Despite increased understanding of TAN …

Aims Previous studies have demonstrated improved cardiac function following myocardial
infarction (MI) after administration of endothelial progenitor cells (EPCs) into ischaemic …

Hepatocellular carcinoma (HCC) is the typical inflammation-induced neoplasia. It often
prospers where a chronic liver disease persists, thus leading a strong rationale for immune …

Colorectal cancer (CRC) is one of the most common cancer types and represents a major
therapeutic challenge. Although initial events in colorectal carcinogenesis are relatively well …

Tumors evade host immune surveillance through multiple mechanisms, including the
generation of a tumor microenvironment that suppresses immune effector function. Secretion …

Antibody‐dependent cellular cytotoxicity (ADCC) is a set of mechanisms that target cells
coated with IgG antibodies of the proper subclasses (IgG1 in the human) to be the prey of …

Inefficient knock-in of transgene cargos limits the potential of cell-based medicines. In this
study, we used a CRISPR nuclease that targets a site within an exon of an essential gene …