Activation of metastatic reprogramming is critical for tumour metastasis. However, more
detailed knowledge of the underlying mechanism is needed to enable targeted intervention …

Collagen triple helix repeat containing‐1 (CTHRC1) has been identified as cancer‐related
protein. CTHRC1 expresses mainly in adventitial fibroblasts and neointimal smooth muscle …

Transforming growth factors (TGFs) were discovered as activities that were secreted by
cancer cells, and later by normal cells, and had the ability to phenotypically and reversibly …

Progress in understanding tumor stromal biology has been constrained in part because
cancer-associated fibroblasts (CAF) are a heterogeneous population with limited cell-type …

The generation and maintenance of CD 8+ T cell memory is crucial to long‐term host
survival, yet the basic tenets of CD 8+ T cell immunity are still being established. Recent …

Abstract KMT2A-rearranged (KMT2A-r) infant acute lymphoblastic leukemia (ALL) is a
devastating malignancy with a dismal outcome, and younger age at diagnosis is associated …

The formation of new blood vessels is essential for normal development, tissue repair and
tumor growth. Here we show that inhibition of the kinase p38α enhances angiogenesis in …

Retaining the delicate balance in cell signaling activity is a prerequisite for the maintenance
of physiological tissue homeostasis. Transforming growth factor‐beta (TGFβ) signaling is an …

The liver is one of the most common sites of breast cancer metastasis and is associated with
high lethality. Although the interaction between tumor cells and their microenvironment at …

Mesenchymalization is a cellular and molecular program in which epithelial cells
progressively lose their well-differentiated phenotype and adopt mesenchymal …