Lipid nanoparticle (LNP) enables mRNA delivery for cancer therapy
Messenger RNA (mRNA) has received great attention in the prevention and treatment of
various diseases due to the success of coronavirus disease 2019 (COVID‐19) mRNA …
various diseases due to the success of coronavirus disease 2019 (COVID‐19) mRNA …
Lipid nanoparticles (LNPs) for in vivo RNA delivery and their breakthrough technology for future applications
RNA therapeutics show a significant breakthrough for the treatment of otherwise incurable
diseases and genetic disorders by regulating disease-related gene expression. The …
diseases and genetic disorders by regulating disease-related gene expression. The …
Strategies for non-viral vectors targeting organs beyond the liver
In recent years, nanoparticles have evolved to a clinical modality to deliver diverse nucleic
acids. Rising interest in nanomedicines comes from proven safety and efficacy profiles …
acids. Rising interest in nanomedicines comes from proven safety and efficacy profiles …
Chemically modified platforms for better RNA therapeutics
RNA-based therapies have catalyzed a revolutionary transformation in the biomedical
landscape, offering unprecedented potential in disease prevention and treatment. However …
landscape, offering unprecedented potential in disease prevention and treatment. However …
Physiological barriers and strategies of lipid‐based nanoparticles for nucleic acid drug delivery
Lipid‐based nanoparticles (LBNPs) are currently the most promising vehicles for nucleic
acid drug (NAD) delivery. Although their clinical applications have achieved success, the …
acid drug (NAD) delivery. Although their clinical applications have achieved success, the …
Recent advances in nanoparticulate RNA delivery systems
Nanoparticle-based RNA delivery has shown great progress in recent years with the
approval of two mRNA vaccines for Severe Acute Respiratory Syndrome Coronavirus 2 …
approval of two mRNA vaccines for Severe Acute Respiratory Syndrome Coronavirus 2 …
Combinatorial design of ionizable lipid nanoparticles for muscle-selective mRNA delivery with minimized off-target effects
Ionizable lipid nanoparticles (LNPs) pivotal to the success of COVID-19 mRNA (messenger
RNA) vaccines hold substantial promise for expanding the landscape of mRNA-based …
RNA) vaccines hold substantial promise for expanding the landscape of mRNA-based …
Functionalized nanoparticles: Tailoring properties through surface energetics and coordination chemistry for advanced biomedical applications
Significant advances in nanoparticle-related research have been made in the past decade,
and amelioration of properties is considered of utmost importance for improving nanoparticle …
and amelioration of properties is considered of utmost importance for improving nanoparticle …
Lipid nanoparticles optimized for targeting and release of nucleic acid
Y Jia, X Wang, L Li, F Li, J Zhang… - Advanced Materials, 2024 - Wiley Online Library
Lipid nanoparticles (LNPs) are currently the most promising clinical nucleic acids drug
delivery vehicles. LNPs prevent the degradation of cargo nucleic acids during blood …
delivery vehicles. LNPs prevent the degradation of cargo nucleic acids during blood …
Nanoparticle-mediated RNA therapy attenuates nonalcoholic steatohepatitis and related fibrosis by targeting activated hepatic stellate cells
Chronic liver injury and inflammation triggered by metabolic abnormalities initiate the
activation of hepatic stellate cells (HSCs), driving fibrosis and parenchymal dysfunction …
activation of hepatic stellate cells (HSCs), driving fibrosis and parenchymal dysfunction …