The therapeutic potential of apelin in kidney disease

FA Chapman, D Nyimanu, JJ Maguire… - Nature Reviews …, 2021 - nature.com
Chronic kidney disease (CKD) is a leading cause of global morbidity and mortality and is
independently associated with cardiovascular disease. The mainstay of treatment for CKD is …

Apelin is Peptide Increasing Tolerance of Organs and Cells to Hypoxia and Reoxygenation. The Signaling Mechanism

SV Popov, LN Maslov, AV Mukhomedzyanov… - International Journal of …, 2024 - Springer
Over the last three decades, treatment of stroke and acute myocardial infarction (AMI) has
been improved, but it has stagnated in the last few years. Patients with stroke and AMI are …

Bioactive peptide apelin rescues acute kidney injury by protecting the function of renal tubular mitochondria

YM Guan, ZL Diao, HD Huang, JF Zheng, QD Zhang… - Amino Acids, 2021 - Springer
Mitochondrial dysfunction in proximal tubular epithelial cells is a key event in acute kidney
injury (AKI), which is a risk factor for the development of chronic kidney disease (CKD) …

[HTML][HTML] Protective effects of limb remote ischemic per-conditioning on the heart injury induced by renal ischemic-reperfusion through the interaction of the apelin with …

S Janfeshan, F Masjedi, Z Karimi - BioImpacts: BI, 2024 - ncbi.nlm.nih.gov
Methods: Renal ischemia-reperfusion injury (I/R) was induced by bilateral occlusion of the
renal pedicles for 60 minutes, followed by 24 hours of reperfusion; sham-operated rats …

Berberis integerrima hydro-alcoholic root extract and its constituent berberine protect against cisplatin-induced nephro-and hepato-toxicity

F Gholampour, R Masoudi, M Khaledi… - The American Journal of …, 2022 - Elsevier
Background This study determined the potential hepato-and renal protective role of
berberine and hydroalcohol extract of Berberis integerrima (barberry) against cisplatin …

Remote ischaemic perconditioning reduces the infarct volume and improves the neurological function of acute ischaemic stroke partially through the miR-153-5p …

H Zha, W Miao, W Rong, A Wang, W Jiang, R Liu… - Folia …, 2021 - termedia.pl
Remote ischemic perconditioning (RIPerC) could improve neuronal damage and inhibit
inflammation and apoptosis. We conducted an in-depth exploration of the protective …

Deleterious Effects of Remote Ischaemic Per-conditioning During Lower Limb Ischaemia–Reperfusion in Mice

M Guillot, AL Charles, A Lejay, J Pottecher… - European Journal of …, 2021 - Elsevier
Objective The aim of this study was to investigate whether remote ischaemic per-
conditioning might protect skeletal muscle during lower limb ischaemia–reperfusion (IR) …

Risk Prediction In Long Term Kidney Transplant Recipients–Model Development Using Apelinergic Markers And Machine Learning Tools

K Batko, A Sączek, M Banaszkiewicz, M Krzanowski… - medRxiv, 2024 - medrxiv.org
Introduction Limited tools exist for predicting kidney function in long-term kidney transplant
recipients (KTRs). Elabela and apelin are APJ receptor agonists that constitute the …

Апелин–пептид, повышающий устойчивость органов и клеток к ишемии и реперфузии. Молекулярный механизм (обзор)

СB Попов, НВ Нарыжная, МА Сиротина… - … журнал клинической и …, 2024 - sibjcem.ru
Аннотация Ишемические-реперфузионные повреждения органов лежат в основе таких
распространенных патологий, как ишемический инсульт и инфаркт миокарда и …

Sıçanlarda Deneysel Böbrek İskemi-Reperfüzyonunda Naringin'in Aquaporin-1 ve Aquaporin-2 Düzeylerine Etkisi

Z Demir - 2022 - acikerisim.selcuk.edu.tr
Özet Böbrek iskemi reperfüzyonu ciddi bir sağlık problemine yol açabileceğinden dolayı
bunun elektrolit su dengesinde oluşturabileceği olumsuz değişimleri önlemede …