Zinc fingers (ZFs) are among the most structurally diverse protein domains. They interact
with nucleic acids, other proteins and lipids to facilitate a multitude of biological processes …

Metal-assisted hydrolysis of peptide bond is a promising alternative for enzymatic cleavage
of proteins with prospective applications in biochemistry and bioengineering. Many metal …

MOF-808, a Zr (IV)-based metal–organic framework, has been proven to be a very effective
heterogeneous catalyst for the hydrolysis of the peptide bond in a wide range of peptides …

Site-specific protein cleavage is essential for many protein-production protocols and
typically requires proteases. We report the development of a chemical protein-cleavage …

Detailed kinetic studies on the hydrolysis of glycylserine (Gly-Ser) and glycylglycine (Gly-
Gly) in the presence of the dimeric zirconium (IV)-substituted Keggin type polyoxometalate …

Fragmentation in the hinge region of an IgG1 monoclonal antibody (mAb) can affect product
stability, potentially causing changes in potency and efficacy. Metals ions, such as Cu2+ …

Recently we screened a combinatorial library of R1-(Ser/Thr)-Xaa-His-Zaa-R2 peptides
(Xaa= 17 common α-amino acids, except Asp, Glu, and Cys; Zaa= 19 common α-amino …

We report for the first time on the selective hydrolysis of a polypeptide system by a metal-
substituted polyoxometalate (POM). Oxidized insulin chain B, a 30 amino acid polypeptide …

Previously we demonstrated for several examples that peptides having a general internal
sequence RN-Yaa-Ser/Thr-Xaa-His-Zaa-RC (Yaa= Glu or Ala, Xaa= Ala or His, Zaa= Lys …

Nickel compounds are included among human carcinogens, though the molecular events
related to them are not yet completely known. It has been proposed that the basic element …