Clinical heterogeneity, unpredictable course and flares are characteristics of systemic lupus
erythematosus (SLE). Although SLE is—by and large—a systemic disease, occasionally it …

Molecular mimicry is one of the leading mechanisms by which infectious or chemical agents
may induce autoimmunity. It occurs when similarities between foreign and self-peptides …

A variety of mechanisms have been suggested as the means by which infections can initiate
and/or exacerbate autoimmune diseases. One mechanism is molecular mimicry, where a …

Systemic lupus erythematosus (SLE) is characterized by multisystem immune-mediated
injury in the setting of autoimmunity to nuclear antigens. The clinical heterogeneity of SLE …

Neutrophils derive from hematopoietic stem cells (HSCs) with systemic inflammation driving
their activation and differentiation to myeloid progenitors to ensure enhanced myelopoiesis …

To advance our understanding and treatment of disease, research immunologists have
been called-upon to place more centralized emphasis on impactful human studies. Such …

Objective MicroRNAs (miRNAs) regulate the expression of genes involved in immune
activation. A study was undertaken to characterise the miRNA signature and identify novel …

Regulatory T cells have been implicated in the regulation and maintenance of immune
homeostasis. Whether gender and sex hormones differentially influence the expression and …

Objective This integrated analysis evaluates the efficacy and safety of voclosporin, a novel
calcineurin inhibitor, at 23.7 mg twice daily in combination with mycophenolate mofetil …

Previous studies of stroke in systemic lupus erythematosus (SLE) have had limited statistical
power, combined stroke subtypes into composite outcomes, and lacked a reference …