The gold drugs, gold sodium thiomalate (Myocrisin), aurothioglucose (Solganal), and the
orally administered auranofin (Ridaura), are utilized in modern medicine for the treatment of …

Although important progress has been made, cancer still remains a complex disease to
treat. Serious side effects, the insurgence of resistance and poor selectivity are some of the …

Gold compounds form a new class of promising anticancer agents with innovative modes of
action. It is generally believed that anticancer gold compounds, at variance with clinically …

Biologics are emerging as the most important class of drugs and are used to treat a large
variety of pathologies. Most of biologics are proteins administered in large amounts, either …

A panel of four novel gold (I) complexes, inspired by the clinically established gold drug
auranofin (1-Thio-β-D-glucopyranosatotriethylphosphine gold-2, 3, 4, 6-tetraacetate), was …

The biological activity of Pd (II) and Pt (II) complexes toward three different cancer cell lines
as well as inhibition of selenoenzyme thioredoxin reductase (TrxR) was modulated in an …

The thioredoxin system is essential for many physiological processes, including the
maintenance of redox signalling pathways. Alterations in the activity, expression and …

Three gold (I) linear compounds, sharing the general formula [AuI (LPh 3)], have been
synthesized and characterized. The nature of the ligand has been modified by moving down …