Genetics and neurobiology of eating disorders
Eating disorders (anorexia nervosa, bulimia nervosa and binge-eating disorder) are a
heterogeneous class of complex illnesses marked by weight and appetite dysregulation …
heterogeneous class of complex illnesses marked by weight and appetite dysregulation …
From compulsivity to compulsion: the neural basis of compulsive disorders
Compulsive behaviour, an apparently irrational perseveration in often maladaptive acts, is a
potential transdiagnostic symptom of several neuropsychiatric disorders, including …
potential transdiagnostic symptom of several neuropsychiatric disorders, including …
Rapid, automated, and experimenter-free touchscreen testing reveals reciprocal interactions between cognitive flexibility and activity-based anorexia in female rats
Anorexia nervosa has among the highest mortality rates of any psychiatric disorder and is
characterized by cognitive inflexibility that persists after weight recovery and contributes to …
characterized by cognitive inflexibility that persists after weight recovery and contributes to …
AgRP neurons coordinate the mitigation of activity-based anorexia
AK Sutton Hickey, SC Duane, LE Mickelsen… - Molecular …, 2023 - nature.com
Anorexia nervosa (AN) is a debilitating and deadly disease characterized by low body mass
index due to diminished food intake, and oftentimes concurrent hyperactivity. A high …
index due to diminished food intake, and oftentimes concurrent hyperactivity. A high …
Psilocybin restrains activity-based anorexia in female rats by enhancing cognitive flexibility: contributions from 5-HT1A and 5-HT2A receptor mechanisms
Psilocybin has shown promise for alleviating symptoms of depression and is currently in
clinical trials for the treatment of anorexia nervosa (AN), a condition that is characterised by …
clinical trials for the treatment of anorexia nervosa (AN), a condition that is characterised by …
Smo-Shh agonist Purmorphamine prevents neurobehavioral and neurochemical defects in 8-OH-DPAT-induced experimental model of obsessive-compulsive …
Obsessive-compulsive disorder is a mental disorder characterized by repetitive, unwanted
thoughts and behavior due to abnormal neuronal corticostriatal-thalamocortical pathway …
thoughts and behavior due to abnormal neuronal corticostriatal-thalamocortical pathway …
A transdiagnostic and translational framework for delineating the neuronal mechanisms of compulsive exercise in anorexia nervosa
Objective The development of novel treatments for anorexia nervosa (AN) requires a
detailed understanding of the biological underpinnings of specific, commonly occurring …
detailed understanding of the biological underpinnings of specific, commonly occurring …
Chemogenetics as a neuromodulatory approach to treating neuropsychiatric diseases and disorders
Chemogenetics enables precise, non-invasive, and reversible modulation of neural activity
via the activation of engineered receptors that are pharmacologically selective to …
via the activation of engineered receptors that are pharmacologically selective to …
[HTML][HTML] Insulin and disorders of behavioural flexibility
M Sullivan, F Fernandez-Aranda… - … & biobehavioral reviews, 2023 - Elsevier
Behavioural inflexibility is a symptom of neuropsychiatric and neurodegenerative disorders
such as Obsessive-Compulsive Disorder, Autism Spectrum Disorder and Alzheimer's …
such as Obsessive-Compulsive Disorder, Autism Spectrum Disorder and Alzheimer's …
Cortical reorganization of the glutamate synapse in the activity‐based anorexia rat model: Impact on cognition
F Mottarlini, G Targa, G Bottan, B Tarenzi… - Journal of …, 2022 - Wiley Online Library
Patients suffering from anorexia nervosa (AN) display altered neural activity, morphological,
and functional connectivity in the fronto‐striatal circuit. In addition, hypoglutamatergic …
and functional connectivity in the fronto‐striatal circuit. In addition, hypoglutamatergic …