The synthesis of cholesterol requires more than 20 enzymes, many of which are intricately
regulated. Post-translational control of these enzymes provides a rapid means for modifying …

The field of sterol and oxysterol biology in lung disease has recently gained attention,
revealing a unique need for sterol uptake and metabolism in the lung. The presence of …

Triphenyl phosphate (TPhP), a prevalent pollutant in the aquatic environment, has been
reported to induce neurotoxicity (eg, a suppression in locomotor activity) in fish larvae …

The intestinal pathogen Clostridioides difficile is the leading cause of antibiotic-associated
diarrhea and pseudomembranous colitis in humans. The symptoms of C. difficile-associated …

During the last decade, the understanding of the biological functions of cholesterol
biosynthesis intermediates has changed significantly. Particularly, the enzyme sterol …

Mouse brain contains over 100 million neuronal, glial, and other support cells. Developing
neurons and astrocytes synthesize their own cholesterol, and disruption of this process can …

Polypharmacy, or the simultaneous use of multiple drugs to treat a single patient, is a
common practice in psychiatry. Unfortunately, data on the health effects of commonly used …

Regeneration of myelin in the central nervous system is being pursued as a potential
therapeutic approach for multiple sclerosis. Several labs have reported small molecules that …

Background Amiodarone is an effective antiarrhythmic drug, which interferes with
cholesterol synthesis. In the human body, it inhibits two enzymes in the cholesterol …

Pertussis toxin (PT) is a virulent factor produced by Bordetella pertussis, the causative agent
of whooping cough. PT exerts its pathogenic effects by ADP-ribosylating heterotrimeric G …