The association of protein kinase CK2 (formerly casein kinase II or 2) with cell growth and
proliferation in cells was apparent at early stages of its investigation. A cancer-specific role …

Protein kinase CK2 is a Ser/Thr protein kinase that phosphorylates hundreds of substrates
mainly related to survival and proliferation pathways. It has long been considered an anti …

Immune cells can protect against tumor progression by killing cancer cells, while aberrant
expression of the immune checkpoint protein PD‐L1 (programmed death ligand 1) in cancer …

Specificity is a limiting factor when using small-molecule inhibitors to study protein kinase
signalling. Since inhibitor-resistant kinase mutants (ie, drug-resistant alleles) remain active …

Gemcitabine, a pivotal chemotherapeutic agent for pancreatic ductal adenocarcinoma
(PDAC), frequently encounters drug resistance, posing a significant clinical challenge with …

The serine/threonine protein kinase CK2 is implicated in the regulation of fundamental
processes in eukaryotic cells. CK2 consists of two catalytic α or α'isoforms and two …

Mass spectrometry-based omics technologies are increasingly used in perturbation studies
to map drug effects to biological pathways by identifying significant molecular events …

Casein Kinase 2 (CSNK2) is an extremely pleiotropic, ubiquitously expressed protein kinase
involved in the regulation of numerous key biological processes. Mapping the CSNK2 …

Dramatic advances in phosphoproteomics and the development of a selective chemical
probe have presented new opportunities for revealing the cellular landscape of substrates …

Casein kinase 2 (CK2) is an evolutionarily conserved serine/threonine kinase implicated in
a wide range of cellular functions and known to be dysregulated in various diseases such as …