Simple Summary Targeted therapies in children with hematological malignancies moderate
the effects of cytotoxic therapy, thus improving survival rates. They have emerged over the …

Immunotherapy in soft tissue sarcoma (STS) has experienced a surge of interest in the past
decade, contributing to an expanding number of therapeutic options for this extremely …

The response rates of pediatric cancers to immune checkpoint inhibitor therapies are
disappointingly low, particularly when compared to the remarkable impact of these drugs in …

Targeting tumor microenvironment and metastasis in children... : Current Opinion in
Pediatrics Targeting tumor microenvironment and metastasis in children with solid tumors …

Background Cancer immunotherapies including immune checkpoint inhibitors and Chimeric
Antigen Receptor (CAR) T-cell therapy have shown variable response rates in paediatric …

Molecular profiling provides the insight that specific genetic alterations can be detected
across a wide range of different histologically characterised tumour types. Thus, the basic …

Objective: In vivo imaging of programmed death ligand 1 (PD-L1) can monitor changes in
PD-L1 expression and target PD-1/PD-L1 therapy. A 99mTc-labeled affibody molecular …

Adrenocortical neoplasms are rare in childhood. Their histopathological categorization into
benign and malignant is often challenging, impacting further management. While the …

Background and aims Extracranial malignant rhabdoid tumours are tumours that mainly
affect young children and have a poor prognosis. In 2014, the European Paediatric Soft …

Background and Aims: Pediatric adrenocortical tumors (ACT) are very rare endocrine
neoplasms in childhood. In this study, we performed a retrospective analysis of children with …