Simple Summary Pediatric adrenocortical tumors are rare. Little information is available on
the incidence, risk factors, prognostic factors, treatment, and overall survival. In this …

Simple Summary Solid cancers can effectively counteract immune attack by inhibitory
checkpoints in the tumor microenvironment. Blockade of relevant immune checkpoints could …

Precision medicine incorporates the unique genetic alterations of a patient's disease to
guide their therapy. One of the earliest well-known examples of precision medicine in the …

Cancer immunotherapies have revolutionized how we can treat adult malignancies and are
being translated to pediatric oncology. Chimeric antigen receptor T-cell therapy and …

Immunotherapy has emerged as a powerful therapeutic strategy for many malignancies,
including lymphoma. As in solid tumors, early clinical trials have revealed that …

Currently-available therapies for newly-diagnosed pediatric and adolescent patients with
Hodgkin lymphoma result in> 95% survival at 5 years. Long-term survivors may suffer from …

Background Molecular profiling of the tumour immune microenvironment (TIME) has
enabled the rational choice of immunotherapies in some adult cancers. In contrast, the TIME …

This review highlights the role of several immunomodulating elements contributing to the
tumor microenvironment of various pediatric renal tumors including Wilms tumor. The roles …

Background The clinical development of immune checkpoint–targeted immunotherapies has
been disappointing so far in paediatric solid tumours. However, as opposed to adults, very …

Simple Summary Neuroblastoma is a common childhood cancer with poor prognosis. Prior
studies suggest that inhibition of molecules called checkpoint proteins, which normally …