[HTML][HTML] Adrenocortical carcinoma in childhood: A systematic review

M Riedmeier, B Decarolis, I Haubitz, S Müller… - Cancers, 2021 - mdpi.com
Simple Summary Pediatric adrenocortical tumors are rare. Little information is available on
the incidence, risk factors, prognostic factors, treatment, and overall survival. In this …

[HTML][HTML] HLA-G and HLA-E immune checkpoints are widely expressed in Ewing sarcoma but have limited functional impact on the effector functions of antigen-specific …

B Altvater, S Kailayangiri, LF Pérez Lanuza, K Urban… - Cancers, 2021 - mdpi.com
Simple Summary Solid cancers can effectively counteract immune attack by inhibitory
checkpoints in the tumor microenvironment. Blockade of relevant immune checkpoints could …

Precision oncology in pediatric cancer surgery

WG Lee, ES Kim - Surgical Oncology Clinics, 2024 - surgonc.theclinics.com
Precision medicine incorporates the unique genetic alterations of a patient's disease to
guide their therapy. One of the earliest well-known examples of precision medicine in the …

Advances in immunotherapeutic targets for childhood cancers: A focus on glypican-2 and B7-H3

N Li, MR Spetz, D Li, M Ho - Pharmacology & therapeutics, 2021 - Elsevier
Cancer immunotherapies have revolutionized how we can treat adult malignancies and are
being translated to pediatric oncology. Chimeric antigen receptor T-cell therapy and …

[HTML][HTML] Engaging the innate and adaptive antitumor immune response in lymphoma

CM Csizmar, SM Ansell - International journal of molecular sciences, 2021 - mdpi.com
Immunotherapy has emerged as a powerful therapeutic strategy for many malignancies,
including lymphoma. As in solid tumors, early clinical trials have revealed that …

[HTML][HTML] Promising drugs and treatment options for pediatric and adolescent patients with Hodgkin lymphoma

V De Re, O Repetto, L Mussolin, G Brisotto… - Frontiers in Cell and …, 2022 - frontiersin.org
Currently-available therapies for newly-diagnosed pediatric and adolescent patients with
Hodgkin lymphoma result in> 95% survival at 5 years. Long-term survivors may suffer from …

[HTML][HTML] A novel transcriptional signature identifies T-cell infiltration in high-risk paediatric cancer

C Mayoh, AJ Gifford, R Terry, LMS Lau, M Wong… - Genome medicine, 2023 - Springer
Background Molecular profiling of the tumour immune microenvironment (TIME) has
enabled the rational choice of immunotherapies in some adult cancers. In contrast, the TIME …

The tumor microenvironment and immune targeting therapy in pediatric renal tumors

AB Hont, B Dumont, KS Sutton… - Pediatric blood & …, 2023 - Wiley Online Library
This review highlights the role of several immunomodulating elements contributing to the
tumor microenvironment of various pediatric renal tumors including Wilms tumor. The roles …

[HTML][HTML] Immune contexture of paediatric cancers

MD Thakur, CJ Franz, L Brennan… - European Journal of …, 2022 - Elsevier
Background The clinical development of immune checkpoint–targeted immunotherapies has
been disappointing so far in paediatric solid tumours. However, as opposed to adults, very …

[HTML][HTML] Expression of immunomodulatory checkpoint molecules in drug-resistant neuroblastoma: an exploratory study

NJ Skertich, F Chu, IAM Tarhoni, S Szajek, JA Borgia… - Cancers, 2022 - mdpi.com
Simple Summary Neuroblastoma is a common childhood cancer with poor prognosis. Prior
studies suggest that inhibition of molecules called checkpoint proteins, which normally …