From influenza to COVID-19: Lipid nanoparticle mRNA vaccines at the frontiers of infectious diseases
Vaccination represents the best line of defense against infectious diseases and is crucial in
curtailing pandemic spread of emerging pathogens to which a population has limited …
curtailing pandemic spread of emerging pathogens to which a population has limited …
The challenge and prospect of mRNA therapeutics landscape
Messenger RNA (mRNA)-based therapeutics hold the potential to cause a major revolution
in the pharmaceutical industry because they can be used for precise and individualized …
in the pharmaceutical industry because they can be used for precise and individualized …
[HTML][HTML] mRNA-based therapeutics—developing a new class of drugs
In vitro transcribed (IVT) mRNA has recently come into focus as a potential new drug class to
deliver genetic information. Such synthetic mRNA can be engineered to transiently express …
deliver genetic information. Such synthetic mRNA can be engineered to transiently express …
Therapeutic cancer vaccines
The clinical benefit of therapeutic cancer vaccines has been established. Whereas
regression of lesions was shown for premalignant lesions caused by HPV, clinical benefit in …
regression of lesions was shown for premalignant lesions caused by HPV, clinical benefit in …
Dendrimer-RNA nanoparticles generate protective immunity against lethal Ebola, H1N1 influenza, and Toxoplasma gondii challenges with a single dose
Vaccines have had broad medical impact, but existing vaccine technologies and production
methods are limited in their ability to respond rapidly to evolving and emerging pathogens …
methods are limited in their ability to respond rapidly to evolving and emerging pathogens …
Nanotechnologies in delivery of mRNA therapeutics using nonviral vector-based delivery systems
S Guan, J Rosenecker - Gene therapy, 2017 - nature.com
Because of its safe and effective protein expression profile, in vitro transcribed messenger
RNA (IVT-mRNA) represents a promising candidate in the development of novel …
RNA (IVT-mRNA) represents a promising candidate in the development of novel …
Engineered nucleic acids encoding a modified erythropoietin and their expression
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
46147671&utm_source= google_patent&utm_medium= platform_link&utm_campaign …
46147671&utm_source= google_patent&utm_medium= platform_link&utm_campaign …
RNA‐based vaccines in cancer immunotherapy
MA McNamara, SK Nair, EK Holl - Journal of immunology …, 2015 - Wiley Online Library
RNA vaccines traditionally consist of messenger RNA synthesized by in vitro transcription
using a bacteriophage RNA polymerase and template DNA that encodes the antigen (s) of …
using a bacteriophage RNA polymerase and template DNA that encodes the antigen (s) of …
Increased erythropoiesis in mice injected with submicrogram quantities of pseudouridine-containing mRNA encoding erythropoietin
K Karikó, H Muramatsu, JM Keller, D Weissman - Molecular Therapy, 2012 - cell.com
Advances in the optimization of in vitro-transcribed mRNA are bringing mRNA-mediated
therapy closer to reality. In cultured cells, we recently achieved high levels of translation with …
therapy closer to reality. In cultured cells, we recently achieved high levels of translation with …
Terminally modified RNA
T Chakraborty, S Bancel, SG Hoge, A Roy… - US Patent …, 2017 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
49447811&utm_source= google_patent&utm_medium= platform_link&utm_campaign …
49447811&utm_source= google_patent&utm_medium= platform_link&utm_campaign …