The peptide hormone leptin regulates food intake, body mass, and reproductive function and
plays a role in fetal growth, proinflammatory immune responses, angiogenesis and lipolysis …

5-HT receptors expressed throughout the human body are targets for established
therapeutics and various drugs in development. Their diversity of structure and function …

This review proposes that physical inactivity could be considered a behavior selected by
evolution for resting, and also selected to be reinforcing in life-threatening situations in …

Brown adipose tissue (BAT) is the main site of adaptive thermogenesis and experimental
studies have associated BAT activity with protection against obesity and metabolic diseases …

Leptin and its receptors have been identified as key regulators of body weight and energy
homeostasis. A decrease in tissue sensitivity to leptin leads to the development of obesity …

Adipose tissue regulates numerous physiological processes, and its dysfunction in obese
humans is associated with disrupted metabolic homeostasis, insulin resistance and type 2 …

Obesity is a worldwide pandemic in adults as well as children and adds greatly to health
care costs through its association with type 2 diabetes, metabolic syndrome, cardiovascular …

During the past 30 yr, investigating the physiology of eating behaviors has generated a truly
vast literature. This is fueled in part by a dramatic increase in obesity and its comorbidities …

Background The diminished glucose lowering effect of insulin in obesity, called “insulin
resistance,” is associated with glucose intolerance, type 2 diabetes, and other serious …

Hunger is controlled by specialized neural circuits that translate homeostatic needs into
motivated behaviors. These circuits are under chronic control by circulating signals of …