The vocal folds are laryngeal connective tissues with complex matrix composition/
organization that provide the viscoelastic mechanical properties required for voice …

OBJECTIVE: Expansion of autologous chondrocytes is a common step in procedures for
cartilage defect repair. Subsequent dedifferentiation can alter cellular response to …

Solute transport through the extracellular matrix is essential for cellular activities in articular
cartilage. Increased solute transport via fluid convection may be a mechanism by which …

The purpose of the study was to investigate whether a relationship between the loading
mode of physical activity and serum cartilage oligomeric matrix protein (COMP) …

Both mechanical loading and interleukin-1β (IL-1β) are known to regulate metabolic
processes in articular cartilage through pathways mediated by nitric oxide (• NO) and PGE2 …

In the present study, the role of mitogen-activated protein kinases (MAPKs) in chondrocyte
mechanotransduction was investigated. We hypothesized that MAPKs participate in fluid …

Confocal laser scanning microscopy (CLSM) is a type of high-resolution fluorescence
microscopy that overcomes the limitations of conventional widefield microscopy and …

Background: Osteoarthritis (OA) is the most common degenerative joint disease without an
ultimate treatment. In a search for novel approaches, tissue engineering (TE) has shown …

Movement-induced forces are critical to correct joint formation, but it is unclear how cells
sense and respond to these mechanical cues. To study the role of mechanical stimuli in the …

Due to the prevalence of osteoarthritis (OA) and damage to articular cartilage, coupled with
the poor intrinsic healing capacity of this avascular connective tissue, there is a great …