Osteoarthritis (OA) is a common joint disease characterized by articular cartilage
degeneration. The etiology of OA is unknown. Because several previous studies have …

Objective: The concept of cartilage functional tissue engineering (FTE) has promoted the
use of physiologic loading bioreactor systems to cultivate engineered tissues with load …

Mechanical forces regulate the structure and function of many tissues in vivo; recent results
indicate that the mechanical environment can decisively influence the development of …

Tissue engineering of articular cartilage is a promising alternative for cartilage repair.
However, it has been difficult to develop tissue in vitro that mimicks native cartilage …

As part of a program of research aimed at determining the role of mechanical forces in
connective tissue differentiation, we have developed a model for investigating the effects of …

Explant loading experiments were conducted to investigate the effect of load duration on
proteoglycan synthesis. A compressive load of 0.1 MPa applied for 10 min was found to …

Biotribology is the science of biological surfaces in sliding contact encompassing the
concepts of friction, wear, and lubrication of interacting surfaces. This bioscience field has …

Objective Traumatic joint injury can initiate early cartilage degeneration in the presence of
elevated inflammatory cytokines (eg, tumor necrosis factor (TNF)-α and interleukin (IL)-6) …

Background: Although tissue engineering of articular cartilage is a promising approach for
cartilage repair, it has been difficult to develop cartilaginous tissue in vitro that mimics the …

Articular cartilage lacks the ability to repair itself and consequently defects in this tissue do
not heal. Tissue engineering approaches, employing a scaffold material and cartilage …