Primary cilia in osteoarthritic chondrocytes: from chondrons to clusters
SR McGlashan, EC Cluett, CG Jensen… - … dynamics: an official …, 2008 - Wiley Online Library
Osteoarthritis (OA) is a common joint disease characterized by articular cartilage
degeneration. The etiology of OA is unknown. Because several previous studies have …
degeneration. The etiology of OA is unknown. Because several previous studies have …
Dynamic mechanical loading enhances functional properties of tissue-engineered cartilage using mature canine chondrocytes
Objective: The concept of cartilage functional tissue engineering (FTE) has promoted the
use of physiologic loading bioreactor systems to cultivate engineered tissues with load …
use of physiologic loading bioreactor systems to cultivate engineered tissues with load …
Effects of mixing intensity on tissue‐engineered cartilage
Mechanical forces regulate the structure and function of many tissues in vivo; recent results
indicate that the mechanical environment can decisively influence the development of …
indicate that the mechanical environment can decisively influence the development of …
Long-term intermittent compressive stimulation improves the composition and mechanical properties of tissue-engineered cartilage
SD Waldman, CG Spiteri, MD Grynpas… - Tissue …, 2004 - liebertpub.com
Tissue engineering of articular cartilage is a promising alternative for cartilage repair.
However, it has been difficult to develop tissue in vitro that mimicks native cartilage …
However, it has been difficult to develop tissue in vitro that mimicks native cartilage …
Chondrocyte differentiation is modulated by frequency and duration of cyclic compressive loading
SH Elder, SA Goldstein, JH Kimura… - Annals of Biomedical …, 2001 - Springer
As part of a program of research aimed at determining the role of mechanical forces in
connective tissue differentiation, we have developed a model for investigating the effects of …
connective tissue differentiation, we have developed a model for investigating the effects of …
Changes in proteoglycan synthesis of chondrocytes in articular cartilage are associated with the time-dependent changes in their mechanical environment
NM Bachrach, WB Valhmu, E Stazzone, A Ratcliffe… - Journal of …, 1995 - Elsevier
Explant loading experiments were conducted to investigate the effect of load duration on
proteoglycan synthesis. A compressive load of 0.1 MPa applied for 10 min was found to …
proteoglycan synthesis. A compressive load of 0.1 MPa applied for 10 min was found to …
The interface of functional biotribology and regenerative medicine in synovial joints
Biotribology is the science of biological surfaces in sliding contact encompassing the
concepts of friction, wear, and lubrication of interacting surfaces. This bioscience field has …
concepts of friction, wear, and lubrication of interacting surfaces. This bioscience field has …
[HTML][HTML] Moderate dynamic compression inhibits pro-catabolic response of cartilage to mechanical injury, tumor necrosis factor-α and interleukin-6, but accentuates …
Y Li, EH Frank, Y Wang, S Chubinskaya… - Osteoarthritis and …, 2013 - Elsevier
Objective Traumatic joint injury can initiate early cartilage degeneration in the presence of
elevated inflammatory cytokines (eg, tumor necrosis factor (TNF)-α and interleukin (IL)-6) …
elevated inflammatory cytokines (eg, tumor necrosis factor (TNF)-α and interleukin (IL)-6) …
Effect of biomechanical conditioning on cartilaginous tissue formation in vitro
SD Waldman, CG Spiteri, MD Grynpas, RM Pilliar… - JBJS, 2003 - journals.lww.com
Background: Although tissue engineering of articular cartilage is a promising approach for
cartilage repair, it has been difficult to develop cartilaginous tissue in vitro that mimics the …
cartilage repair, it has been difficult to develop cartilaginous tissue in vitro that mimics the …
Cartilage tissue engineering: controversy in the effect of oxygen
J Malda, DE Martens, J Tramper… - Critical reviews in …, 2003 - Taylor & Francis
Articular cartilage lacks the ability to repair itself and consequently defects in this tissue do
not heal. Tissue engineering approaches, employing a scaffold material and cartilage …
not heal. Tissue engineering approaches, employing a scaffold material and cartilage …