Articular cartilage is composed of phenotypically different zones. In young articular cartilage,
there are only two distinct zones: superficial and growth. The zones have different …

Ca2+ signaling forms part of a possible mechanotransduction pathway by which
chondrocytes may alter their metabolism in response to mechanical loading. In this study, a …

Background: Altered local mechanical loading may disrupt normal cartilage homeostasis
and play a role in the progression of osteoarthritis. Currently, there are limited data …

The effects of short-and long-term load-controlled compression on the levels of aggrecan
mRNA have been determined. Results show that a compressive stress of 0.1 MPa on bovine …

The temporal response of chondrocyte metabolism in agarose constructs subjected to
different dynamic compression regimes was investigated. The current study explored the …

Objective To assess matrix changes and chondrocyte viability during static and continuous
repetitive mechanical loading in mature bovine articular cartilage explants …

Chondrocytes regulate the composition of cartilage extracellular matrix in response to
mechanical signals, but the intracellular pathways involved in mechanotransduction are still …

The goal of this study was to examine the simultaneous effects of mechanical compression
of chondrocytes on mRNA expression and macromolecular synthesis of aggrrecan and type …

The objective of this study was to investigate the influence of dynamic compressive loading
on chondrogenesis of mesenchymal stem cells (MSCs) in the presence of TGF-β3. Isolated …

The zone of calcified cartilage is the mineralized region of articular cartilage that anchors the
hyaline cartilage to the subchondral bone and serves to disperse mechanical forces across …