The actin filament is astonishingly well conserved across a diverse set of eukaryotic species.
It has essentially remained unchanged in the billion years that separate yeast, Arabidopsis …

Tropomyosin (Tpm) isoforms are the master regulators of the functions of individual actin
filaments in fungi and metazoans. Tpms are coiled-coil parallel dimers that form a head-to …

The actin depolymerizing factor (ADF)/cofilin family comprises small actin-binding proteins
with crucial roles in development, tissue homeostasis and disease. They are best known for …

Stress fibers (SFs) are often the most prominent cytoskeletal structures in cells growing in
tissue culture. Composed of actin filaments, myosin II, and many other proteins, SFs are …

Recent findings have significantly expanded our understanding of the regulation of actin-
depolymerizing factor (ADF)/cofilin proteins and the profound multifaceted impact that these …

Cancer cell metastasis is a multi-stage process involving invasion into surrounding tissue,
intravasation, transit in the blood or lymph, extravasation, and growth at a new site. Many of …

Apoptosis is an important biological process required for the removal of unwanted or
damaged cells. Mounting evidence implicates the actin cytoskeleton as both a sensor and …

Tropomyosins are rodlike coiled coil dimers that form continuous polymers along the major
groove of most actin filaments. In striated muscle, tropomyosin regulates the actin-myosin …

Background Cell migration and morphogenesis are driven by both protrusive and contractile
actin filament structures. The assembly mechanisms of lamellipodial and filopodial actin …

Actin filaments assemble into a variety of networks to provide force for diverse cellular
processes [1]. Tropomyosins are coiled-coil dimers that form head-to-tail polymers along …